Email this article Reaction of Lymphoid Organs to Injection of Iron-Carbon Nanoparticles
- Authors: Khramtsova Y.S.1,2, Tyumentseva N.V.1,3, Yushkov B.G.1,2,3, Silant’eva E.A.2, Medvedeva S.Y.1,2,3, Byzov I.V.4, Uimin M.A.4, Ermakov A.E.4
-
Affiliations:
- Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences
- B. N. Eltsin Ural Federal University
- Institute of Medical Cell Technologies
- M. N. Mikheev Institute of Metal Physics, the Ural Division of the Russian Academy of Sciences
- Issue: Vol 162, No 2 (2016)
- Pages: 252-254
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238090
- DOI: https://doi.org/10.1007/s10517-016-3588-7
- ID: 238090
Cite item
Open Access
Access granted
Subscription Access
Abstract
The distribution of iron-carbon nanoparticles in FeC-DSPE-PEG-2000 modification (micellar particles with structure (Fe) core-carbon shell; PEG-based coating) is studied. The greater part of the nanoparticles accumulated in the spleen and liver, a small amount in the lungs, and the minimum amount in the thymus. The structural changes in the lymphoid organs were minor and involved only the microcirculatory bed. Analysis of the peripheral blood showed manifest anemia, thrombocytopenia, and leukocytosis.
About the authors
Yu. S. Khramtsova
Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences; B. N. Eltsin Ural Federal University
Author for correspondence.
Email: hramtsova15@mail.ru
Russian Federation, Ekaterinburg; Ekaterinburg
N. V. Tyumentseva
Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences; Institute of Medical Cell Technologies
Email: hramtsova15@mail.ru
Russian Federation, Ekaterinburg; Ekaterinburg
B. G. Yushkov
Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences; B. N. Eltsin Ural Federal University; Institute of Medical Cell Technologies
Email: hramtsova15@mail.ru
Russian Federation, Ekaterinburg; Ekaterinburg; Ekaterinburg
E. A. Silant’eva
B. N. Eltsin Ural Federal University
Email: hramtsova15@mail.ru
Russian Federation, Ekaterinburg
S. Yu. Medvedeva
Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences; B. N. Eltsin Ural Federal University; Institute of Medical Cell Technologies
Email: hramtsova15@mail.ru
Russian Federation, Ekaterinburg; Ekaterinburg; Ekaterinburg
I. V. Byzov
M. N. Mikheev Institute of Metal Physics, the Ural Division of the Russian Academy of Sciences
Email: hramtsova15@mail.ru
Russian Federation, Ekaterinburg
M. A. Uimin
M. N. Mikheev Institute of Metal Physics, the Ural Division of the Russian Academy of Sciences
Email: hramtsova15@mail.ru
Russian Federation, Ekaterinburg
A. E. Ermakov
M. N. Mikheev Institute of Metal Physics, the Ural Division of the Russian Academy of Sciences
Email: hramtsova15@mail.ru
Russian Federation, Ekaterinburg
Supplementary files
