Selective Blockade of α2-Adrenoceptor Subtypes Modulates Contractility of Rat Myocardium
- Authors: Zefirov T.L.1, Khisamieva L.I.1, Ziyatdinova N.I.1, Zefirov A.L.2
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Affiliations:
- Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University
- Department of Normal Physiology, Kazan State Medical University
- Issue: Vol 162, No 2 (2016)
- Pages: 177-179
- Section: Physiology
- URL: https://journals.rcsi.science/0007-4888/article/view/238010
- DOI: https://doi.org/10.1007/s10517-016-3569-x
- ID: 238010
Cite item
Abstract
The study examined the dose-dependent effects of selective antagonists of α2A/D-, α2B-, and α2C- adrenoceptors applied in concentrations of 10—9-10—5 M on atrial and ventricular contractility of rat myocardium in vitro. Selective blockade of each α2-adrenoceptor subtype affected the contractile force of the atrial and ventricular strips. Various concentrations of α2A/D- and α2C-adrenoceptor antagonists produced positive inotropic effect on ventricular strips and negative effect on atrial strips. α2B-Adrenoceptor blocker in the majority of the tested concentrations produced a positive inotropic effect in both atria and ventricles.
About the authors
T. L. Zefirov
Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University
Author for correspondence.
Email: zefirovtl@mail.ru
Russian Federation, Kazan, the Republic of Tatarstan
L. I. Khisamieva
Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University
Email: zefirovtl@mail.ru
Russian Federation, Kazan, the Republic of Tatarstan
N. I. Ziyatdinova
Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University
Email: zefirovtl@mail.ru
Russian Federation, Kazan, the Republic of Tatarstan
A. L. Zefirov
Department of Normal Physiology, Kazan State Medical University
Email: zefirovtl@mail.ru
Russian Federation, Kazan, the Republic of Tatarstan