Enviar artigo por via de e-mail Selective Blockade of α2-Adrenoceptor Subtypes Modulates Contractility of Rat Myocardium
- Autores: Zefirov T.1, Khisamieva L.1, Ziyatdinova N.1, Zefirov A.2
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Afiliações:
- Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University
- Department of Normal Physiology, Kazan State Medical University
- Edição: Volume 162, Nº 2 (2016)
- Páginas: 177-179
- Seção: Physiology
- URL: https://journals.rcsi.science/0007-4888/article/view/238010
- DOI: https://doi.org/10.1007/s10517-016-3569-x
- ID: 238010
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Resumo
The study examined the dose-dependent effects of selective antagonists of α2A/D-, α2B-, and α2C- adrenoceptors applied in concentrations of 10—9-10—5 M on atrial and ventricular contractility of rat myocardium in vitro. Selective blockade of each α2-adrenoceptor subtype affected the contractile force of the atrial and ventricular strips. Various concentrations of α2A/D- and α2C-adrenoceptor antagonists produced positive inotropic effect on ventricular strips and negative effect on atrial strips. α2B-Adrenoceptor blocker in the majority of the tested concentrations produced a positive inotropic effect in both atria and ventricles.
Sobre autores
T. Zefirov
Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University
Autor responsável pela correspondência
Email: zefirovtl@mail.ru
Rússia, Kazan, the Republic of Tatarstan
L. Khisamieva
Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University
Email: zefirovtl@mail.ru
Rússia, Kazan, the Republic of Tatarstan
N. Ziyatdinova
Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University
Email: zefirovtl@mail.ru
Rússia, Kazan, the Republic of Tatarstan
A. Zefirov
Department of Normal Physiology, Kazan State Medical University
Email: zefirovtl@mail.ru
Rússia, Kazan, the Republic of Tatarstan
