Ketamine-Midazolam Anesthesia Induces Total Inhibition of Cortical Activity in the Brain of Newborn Rats
- Authors: Lebedeva Y.A.1,2, Zakharova A.V.1,3, Sitdikova G.F.1, Zefirov A.L.3, Khazipov R.N.1,2,4
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Affiliations:
- Kazan (Volga Region) Federal University
- Mediterranean Institute of Neurobiology (INMED)
- Kazan State Medical University, Ministry of Health of the Russian Federation
- Aix-Marseille University
- Issue: Vol 161, No 1 (2016)
- Pages: 15-19
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237053
- DOI: https://doi.org/10.1007/s10517-016-3334-1
- ID: 237053
Cite item
Abstract
The effects of general anesthetics ketamine and midazolam, the drugs that cause neuroapoptosis at the early stages of CNS development, on electrical activity of the somatosensory cortex in newborn rats were studied using extracellular recording of local field potentials and action potentials of cortical neurons. Combined administration of ketamine (40 mg/kg) and midazolam (9 mg/kg) induced surgical coma and almost completely suppressed early oscillatory patterns and neuronal firing. These effects persisted over 3 h after injection of the anesthetics. We concluded that general anesthesia induced by combined administration of ketamine and midazolam profoundly suppressed cortical activity in newborn rats, which can trigger neuroapoptosis in the developing brain.
About the authors
Yu. A. Lebedeva
Kazan (Volga Region) Federal University; Mediterranean Institute of Neurobiology (INMED)
Email: roustem.khazipov@inserm.fr
Russian Federation, Kazan; Marseille
A. V. Zakharova
Kazan (Volga Region) Federal University; Kazan State Medical University, Ministry of Health of the Russian Federation
Email: roustem.khazipov@inserm.fr
Russian Federation, Kazan; Kazan, Tatarstan Republic
G. F. Sitdikova
Kazan (Volga Region) Federal University
Email: roustem.khazipov@inserm.fr
Russian Federation, Kazan
A. L. Zefirov
Kazan State Medical University, Ministry of Health of the Russian Federation
Email: roustem.khazipov@inserm.fr
Russian Federation, Kazan, Tatarstan Republic
R. N. Khazipov
Kazan (Volga Region) Federal University; Mediterranean Institute of Neurobiology (INMED); Aix-Marseille University
Author for correspondence.
Email: roustem.khazipov@inserm.fr
Russian Federation, Kazan; Marseille; Marseille