Ketamine-Midazolam Anesthesia Induces Total Inhibition of Cortical Activity in the Brain of Newborn Rats
- 作者: Lebedeva Y.1,2, Zakharova A.1,3, Sitdikova G.1, Zefirov A.3, Khazipov R.1,2,4
-
隶属关系:
- Kazan (Volga Region) Federal University
- Mediterranean Institute of Neurobiology (INMED)
- Kazan State Medical University, Ministry of Health of the Russian Federation
- Aix-Marseille University
- 期: 卷 161, 编号 1 (2016)
- 页面: 15-19
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237053
- DOI: https://doi.org/10.1007/s10517-016-3334-1
- ID: 237053
如何引用文章
详细
The effects of general anesthetics ketamine and midazolam, the drugs that cause neuroapoptosis at the early stages of CNS development, on electrical activity of the somatosensory cortex in newborn rats were studied using extracellular recording of local field potentials and action potentials of cortical neurons. Combined administration of ketamine (40 mg/kg) and midazolam (9 mg/kg) induced surgical coma and almost completely suppressed early oscillatory patterns and neuronal firing. These effects persisted over 3 h after injection of the anesthetics. We concluded that general anesthesia induced by combined administration of ketamine and midazolam profoundly suppressed cortical activity in newborn rats, which can trigger neuroapoptosis in the developing brain.
作者简介
Yu. Lebedeva
Kazan (Volga Region) Federal University; Mediterranean Institute of Neurobiology (INMED)
Email: roustem.khazipov@inserm.fr
俄罗斯联邦, Kazan; Marseille
A. Zakharova
Kazan (Volga Region) Federal University; Kazan State Medical University, Ministry of Health of the Russian Federation
Email: roustem.khazipov@inserm.fr
俄罗斯联邦, Kazan; Kazan, Tatarstan Republic
G. Sitdikova
Kazan (Volga Region) Federal University
Email: roustem.khazipov@inserm.fr
俄罗斯联邦, Kazan
A. Zefirov
Kazan State Medical University, Ministry of Health of the Russian Federation
Email: roustem.khazipov@inserm.fr
俄罗斯联邦, Kazan, Tatarstan Republic
R. Khazipov
Kazan (Volga Region) Federal University; Mediterranean Institute of Neurobiology (INMED); Aix-Marseille University
编辑信件的主要联系方式.
Email: roustem.khazipov@inserm.fr
俄罗斯联邦, Kazan; Marseille; Marseille