Email this article Local Treatment of Local Staphylococcal Infection with Complex Preparations Based on Metal Nanoparticles in the Experiment
- Authors: Babushkina I.V.1, Mamonova I.A.1, Ulyanov V.Y.1
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Affiliations:
- Research Institute of Traumatology, Orthopedics, and Neurosurgery, V. I. Razumovsky Saratov Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 167, No 6 (2019)
- Pages: 784-786
- Section: Biotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/242115
- DOI: https://doi.org/10.1007/s10517-019-04622-w
- ID: 242115
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Abstract
Antibacterial activity of powdered preparations based on copper and silver nanoparticles was compared with activity of the reference preparation Baneocin on the model of local staphylococcal infection in white rats. The developed preparations exhibited pronounced antibacterial activity against methicillin-resistant S. epidermidis strains in vivo significantly (p<0.001) exceeding that of Baneocin, reduced microbial contamination of the wound on day 5 of study by 2 lg and more in comparison with bacterial load before treatment, and provided effective decontamination of the wound within 7-10 days.
About the authors
I. V. Babushkina
Research Institute of Traumatology, Orthopedics, and Neurosurgery, V. I. Razumovsky Saratov Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: 10051968@mail.ru
Russian Federation, Saratov
I. A. Mamonova
Research Institute of Traumatology, Orthopedics, and Neurosurgery, V. I. Razumovsky Saratov Medical University, Ministry of Health of the Russian Federation
Email: 10051968@mail.ru
Russian Federation, Saratov
V. Yu. Ulyanov
Research Institute of Traumatology, Orthopedics, and Neurosurgery, V. I. Razumovsky Saratov Medical University, Ministry of Health of the Russian Federation
Email: 10051968@mail.ru
Russian Federation, Saratov
