Email this article Morphological Changes in the Thymus of Newborn Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during the Prenatal Period
- Authors: Yaglova N.V.1, Tsomartova E.S.2, Nazimova S.V.1, Obernikhin S.S.1, Mukhamedova S.G.2, Pashina N.R.2, Musaeva D.O.2
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Affiliations:
- Laboratory of Endocrine System Development, Research Institute of Human Morphology
- Department of Histology, Cytology, and Embryology, I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation
- Issue: Vol 167, No 2 (2019)
- Pages: 297-299
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241662
- DOI: https://doi.org/10.1007/s10517-019-04513-0
- ID: 241662
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Abstract
The structure of the thymus in newborn rats exposed in utero to endocrine disruptor DDT was studied. We found that exposure to low doses of DDT during pregnancy does not disturb thymus formation in the offspring, but leads to changes in its structure than manifested as slower lobulation, wider epithelium-free areas in the cortex, and lower number of thymic corpuscles in the medulla. The results attest to sensitivity of the reticuloepithelial stroma of the thymus to the effects of endocrine disruptor.
About the authors
N. V. Yaglova
Laboratory of Endocrine System Development, Research Institute of Human Morphology
Author for correspondence.
Email: yaglova@mail.ru
Russian Federation, Moscow
E. S. Tsomartova
Department of Histology, Cytology, and Embryology, I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation
Email: yaglova@mail.ru
Russian Federation, Moscow
S. V. Nazimova
Laboratory of Endocrine System Development, Research Institute of Human Morphology
Email: yaglova@mail.ru
Russian Federation, Moscow
S. S. Obernikhin
Laboratory of Endocrine System Development, Research Institute of Human Morphology
Email: yaglova@mail.ru
Russian Federation, Moscow
S. G. Mukhamedova
Department of Histology, Cytology, and Embryology, I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation
Email: yaglova@mail.ru
Russian Federation, Moscow
N. R. Pashina
Department of Histology, Cytology, and Embryology, I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation
Email: yaglova@mail.ru
Russian Federation, Moscow
D. O. Musaeva
Department of Histology, Cytology, and Embryology, I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation
Email: yaglova@mail.ru
Russian Federation, Moscow
