Email this article Selective Action of N-Arachidonoyl Dopamine on Viability and Proliferation of Stromal Cells from Eutopic and Ectopic Endometrium
- Authors: Ashba A.M.1,2, Yushina M.N.1, Fedorova-Gogolina I.A.1, Gretskaya N.M.2, Bezuglov V.V.2, Melkumyan A.G.1, Pavlovich S.V.1, Bobrov M.Y.1,2
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Affiliations:
- V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Issue: Vol 167, No 1 (2019)
- Pages: 43-46
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241431
- DOI: https://doi.org/10.1007/s10517-019-04456-6
- ID: 241431
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Abstract
We performed a comparative study of the cytotoxic effect of endocannabinoid N-arachidonoyl dopamine (AA-DA) on cultured stromal cells of ectopic and eutopic endometrium. It was found that AA-DA in the concentration range of 1-20 μM produces more selective cytotoxic effect on the stromal cells of the ectopic endometrium due to interaction with cannabinoid type 1 receptor. In concentrations below 1 μM, AA-DA stimulated the proliferation of stromal cells of the eutopic endometrium and did not affect the division of ectopic endometrium cells. This effect was realized due to its interaction with cannabinoid type 2 receptor.
About the authors
A. M. Ashba
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: mbobr@mail.ru
Russian Federation, Moscow; Moscow
M. N. Yushina
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: mbobr@mail.ru
Russian Federation, Moscow
I. A. Fedorova-Gogolina
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: mbobr@mail.ru
Russian Federation, Moscow
N. M. Gretskaya
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: mbobr@mail.ru
Russian Federation, Moscow
V. V. Bezuglov
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: mbobr@mail.ru
Russian Federation, Moscow
A. G. Melkumyan
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: mbobr@mail.ru
Russian Federation, Moscow
S. V. Pavlovich
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: mbobr@mail.ru
Russian Federation, Moscow
M. Yu. Bobrov
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: mbobr@mail.ru
Russian Federation, Moscow; Moscow
