Selective Action of N-Arachidonoyl Dopamine on Viability and Proliferation of Stromal Cells from Eutopic and Ectopic Endometrium
- 作者: Ashba A.1,2, Yushina M.1, Fedorova-Gogolina I.1, Gretskaya N.2, Bezuglov V.2, Melkumyan A.1, Pavlovich S.1, Bobrov M.1,2
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隶属关系:
- V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- 期: 卷 167, 编号 1 (2019)
- 页面: 43-46
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241431
- DOI: https://doi.org/10.1007/s10517-019-04456-6
- ID: 241431
如何引用文章
详细
We performed a comparative study of the cytotoxic effect of endocannabinoid N-arachidonoyl dopamine (AA-DA) on cultured stromal cells of ectopic and eutopic endometrium. It was found that AA-DA in the concentration range of 1-20 μM produces more selective cytotoxic effect on the stromal cells of the ectopic endometrium due to interaction with cannabinoid type 1 receptor. In concentrations below 1 μM, AA-DA stimulated the proliferation of stromal cells of the eutopic endometrium and did not affect the division of ectopic endometrium cells. This effect was realized due to its interaction with cannabinoid type 2 receptor.
作者简介
A. Ashba
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: mbobr@mail.ru
俄罗斯联邦, Moscow; Moscow
M. Yushina
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: mbobr@mail.ru
俄罗斯联邦, Moscow
I. Fedorova-Gogolina
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: mbobr@mail.ru
俄罗斯联邦, Moscow
N. Gretskaya
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: mbobr@mail.ru
俄罗斯联邦, Moscow
V. Bezuglov
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: mbobr@mail.ru
俄罗斯联邦, Moscow
A. Melkumyan
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: mbobr@mail.ru
俄罗斯联邦, Moscow
S. Pavlovich
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: mbobr@mail.ru
俄罗斯联邦, Moscow
M. Bobrov
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: mbobr@mail.ru
俄罗斯联邦, Moscow; Moscow