A Low-Molecular-Weight Phenotype of Apolipoprotein(a) as a Factor Provoking Accumulation of Cholesterol by THP-1 Monocyte-Like Cells
- Authors: Afanas’eva O.I.1, Vikhrova E.B.1, Razova O.A.1, Utkina E.A.1, Afanas’eva M.I.1, Klesareva E.A.1, Radyukhina N.V.1, Aref’eva T.I.1, Pokrovsky S.N.1
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Affiliations:
- National Medical Research Center of Cardiology, Ministry of Health of the Russia
- Issue: Vol 167, No 1 (2019)
- Pages: 24-29
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241416
- DOI: https://doi.org/10.1007/s10517-019-04452-w
- ID: 241416
Cite item
Abstract
Increased concentration of lipoprotein(a) is a risk factor of coronary heart disease. lipoprotein(a) consists of LDL-like and highly polymorphic apolipoprotein(a). Here we studied the effect of lipoprotein(a)-containing sera with different apolipoprotein(a) phenotypes on lipid accumulation by THP-1 monocyte-like cells. Cholesterol concentration in lysates of THP-1 cells was significantly higher after their incubation with lipoprotein(a)-containing serum samples with low-molecular-weight phenotype of apolipoprotein(a) in comparison with samples with a high-molecular-weight apolipoprotein(a) phenotype irrespective of initial cholesterol level as well as serum concentrations of apoB-100, oxidized LDL, and circulating immune complexes. The presence of the most atherogenic small dense LDL subfractions in examined sera in addition to a low-molecular-weight apolipoprotein(a) phenotype resulted in significant elevation of cholesterol accumulation by THP-1 cells. The data obtained explain greater atherogenicity of lipoprotein(a) with low-molecular-weight apolipoprotein(a) phenotype.
About the authors
O. I. Afanas’eva
National Medical Research Center of Cardiology, Ministry of Health of the Russia
Author for correspondence.
Email: afanasieva.cardio@yandex.ru
Russian Federation, Moscow
E. B. Vikhrova
National Medical Research Center of Cardiology, Ministry of Health of the Russia
Email: afanasieva.cardio@yandex.ru
Russian Federation, Moscow
O. A. Razova
National Medical Research Center of Cardiology, Ministry of Health of the Russia
Email: afanasieva.cardio@yandex.ru
Russian Federation, Moscow
E. A. Utkina
National Medical Research Center of Cardiology, Ministry of Health of the Russia
Email: afanasieva.cardio@yandex.ru
Russian Federation, Moscow
M. I. Afanas’eva
National Medical Research Center of Cardiology, Ministry of Health of the Russia
Email: afanasieva.cardio@yandex.ru
Russian Federation, Moscow
E. A. Klesareva
National Medical Research Center of Cardiology, Ministry of Health of the Russia
Email: afanasieva.cardio@yandex.ru
Russian Federation, Moscow
N. V. Radyukhina
National Medical Research Center of Cardiology, Ministry of Health of the Russia
Email: afanasieva.cardio@yandex.ru
Russian Federation, Moscow
T. I. Aref’eva
National Medical Research Center of Cardiology, Ministry of Health of the Russia
Email: afanasieva.cardio@yandex.ru
Russian Federation, Moscow
S. N. Pokrovsky
National Medical Research Center of Cardiology, Ministry of Health of the Russia
Email: afanasieva.cardio@yandex.ru
Russian Federation, Moscow
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