A Low-Molecular-Weight Phenotype of Apolipoprotein(a) as a Factor Provoking Accumulation of Cholesterol by THP-1 Monocyte-Like Cells
- Авторы: Afanas’eva O.1, Vikhrova E.1, Razova O.1, Utkina E.1, Afanas’eva M.1, Klesareva E.1, Radyukhina N.1, Aref’eva T.1, Pokrovsky S.1
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Учреждения:
- National Medical Research Center of Cardiology, Ministry of Health of the Russia
- Выпуск: Том 167, № 1 (2019)
- Страницы: 24-29
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241416
- DOI: https://doi.org/10.1007/s10517-019-04452-w
- ID: 241416
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Аннотация
Increased concentration of lipoprotein(a) is a risk factor of coronary heart disease. lipoprotein(a) consists of LDL-like and highly polymorphic apolipoprotein(a). Here we studied the effect of lipoprotein(a)-containing sera with different apolipoprotein(a) phenotypes on lipid accumulation by THP-1 monocyte-like cells. Cholesterol concentration in lysates of THP-1 cells was significantly higher after their incubation with lipoprotein(a)-containing serum samples with low-molecular-weight phenotype of apolipoprotein(a) in comparison with samples with a high-molecular-weight apolipoprotein(a) phenotype irrespective of initial cholesterol level as well as serum concentrations of apoB-100, oxidized LDL, and circulating immune complexes. The presence of the most atherogenic small dense LDL subfractions in examined sera in addition to a low-molecular-weight apolipoprotein(a) phenotype resulted in significant elevation of cholesterol accumulation by THP-1 cells. The data obtained explain greater atherogenicity of lipoprotein(a) with low-molecular-weight apolipoprotein(a) phenotype.
Об авторах
O. Afanas’eva
National Medical Research Center of Cardiology, Ministry of Health of the Russia
Автор, ответственный за переписку.
Email: afanasieva.cardio@yandex.ru
Россия, Moscow
E. Vikhrova
National Medical Research Center of Cardiology, Ministry of Health of the Russia
Email: afanasieva.cardio@yandex.ru
Россия, Moscow
O. Razova
National Medical Research Center of Cardiology, Ministry of Health of the Russia
Email: afanasieva.cardio@yandex.ru
Россия, Moscow
E. Utkina
National Medical Research Center of Cardiology, Ministry of Health of the Russia
Email: afanasieva.cardio@yandex.ru
Россия, Moscow
M. Afanas’eva
National Medical Research Center of Cardiology, Ministry of Health of the Russia
Email: afanasieva.cardio@yandex.ru
Россия, Moscow
E. Klesareva
National Medical Research Center of Cardiology, Ministry of Health of the Russia
Email: afanasieva.cardio@yandex.ru
Россия, Moscow
N. Radyukhina
National Medical Research Center of Cardiology, Ministry of Health of the Russia
Email: afanasieva.cardio@yandex.ru
Россия, Moscow
T. Aref’eva
National Medical Research Center of Cardiology, Ministry of Health of the Russia
Email: afanasieva.cardio@yandex.ru
Россия, Moscow
S. Pokrovsky
National Medical Research Center of Cardiology, Ministry of Health of the Russia
Email: afanasieva.cardio@yandex.ru
Россия, Moscow