Comparison of Reactivity of the Lipid Peroxidation–Antioxidant Defense System in Normal and Hypertensive Rats at Different Stages of Stress-Reaction
- Authors: Kolesnikova L.I.1, Kolesnikova L.R.1,2, Darenskaya M.A.1, Natyaganova L.V.1, Grebenkina L.A.1, Korytov L.I.2, Kolesnikov S.I.1,3
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Affiliations:
- Research Center for Family Health and Human Reproduction Problems
- Irkutsk State Medical University, Ministry of Health of the Russian Federation
- M. V. Lomonosov Moscow State University
- Issue: Vol 166, No 5 (2019)
- Pages: 613-616
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241230
- DOI: https://doi.org/10.1007/s10517-019-04403-5
- ID: 241230
Cite item
Abstract
We compared changes in the parameters of LPO—antioxidant defense system at various stages of the stress response in mature male ISIAH rats (hereditary stress-induced arterial hypertension) and WAG rats in 3 h (stage of anxiety) and 7 days (resistance stage) after a 3-h single immobilization in the supine position. It was found that post-stress reactivity of the nonspecific stress-limiting LPO system is different in normotensive and hypertensive rats. ISIAH rats, irrespective of the stage of the stress-reaction, demonstrated more intense LPO reactions (accumulation of TBA-reactive products) and reduced antioxidant defense parameters (low content of lipid-soluble vitamins, increased oxidized glutathione content) in comparison with the corresponding parameters in WAG rats.
About the authors
L. I. Kolesnikova
Research Center for Family Health and Human Reproduction Problems
Email: marina_darenskaya@inbox.ru
Russian Federation, Irkutsk
L. R. Kolesnikova
Research Center for Family Health and Human Reproduction Problems; Irkutsk State Medical University, Ministry of Health of the Russian Federation
Email: marina_darenskaya@inbox.ru
Russian Federation, Irkutsk; Irkutsk
M. A. Darenskaya
Research Center for Family Health and Human Reproduction Problems
Author for correspondence.
Email: marina_darenskaya@inbox.ru
Russian Federation, Irkutsk
L. V. Natyaganova
Research Center for Family Health and Human Reproduction Problems
Email: marina_darenskaya@inbox.ru
Russian Federation, Irkutsk
L. A. Grebenkina
Research Center for Family Health and Human Reproduction Problems
Email: marina_darenskaya@inbox.ru
Russian Federation, Irkutsk
L. I. Korytov
Irkutsk State Medical University, Ministry of Health of the Russian Federation
Email: marina_darenskaya@inbox.ru
Russian Federation, Irkutsk
S. I. Kolesnikov
Research Center for Family Health and Human Reproduction Problems; M. V. Lomonosov Moscow State University
Email: marina_darenskaya@inbox.ru
Russian Federation, Irkutsk; Moscow
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