Comparison of Reactivity of the Lipid Peroxidation–Antioxidant Defense System in Normal and Hypertensive Rats at Different Stages of Stress-Reaction
- Авторы: Kolesnikova L.1, Kolesnikova L.1,2, Darenskaya M.1, Natyaganova L.1, Grebenkina L.1, Korytov L.2, Kolesnikov S.1,3
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Учреждения:
- Research Center for Family Health and Human Reproduction Problems
- Irkutsk State Medical University, Ministry of Health of the Russian Federation
- M. V. Lomonosov Moscow State University
- Выпуск: Том 166, № 5 (2019)
- Страницы: 613-616
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241230
- DOI: https://doi.org/10.1007/s10517-019-04403-5
- ID: 241230
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Аннотация
We compared changes in the parameters of LPO—antioxidant defense system at various stages of the stress response in mature male ISIAH rats (hereditary stress-induced arterial hypertension) and WAG rats in 3 h (stage of anxiety) and 7 days (resistance stage) after a 3-h single immobilization in the supine position. It was found that post-stress reactivity of the nonspecific stress-limiting LPO system is different in normotensive and hypertensive rats. ISIAH rats, irrespective of the stage of the stress-reaction, demonstrated more intense LPO reactions (accumulation of TBA-reactive products) and reduced antioxidant defense parameters (low content of lipid-soluble vitamins, increased oxidized glutathione content) in comparison with the corresponding parameters in WAG rats.
Об авторах
L. Kolesnikova
Research Center for Family Health and Human Reproduction Problems
Email: marina_darenskaya@inbox.ru
Россия, Irkutsk
L. Kolesnikova
Research Center for Family Health and Human Reproduction Problems; Irkutsk State Medical University, Ministry of Health of the Russian Federation
Email: marina_darenskaya@inbox.ru
Россия, Irkutsk; Irkutsk
M. Darenskaya
Research Center for Family Health and Human Reproduction Problems
Автор, ответственный за переписку.
Email: marina_darenskaya@inbox.ru
Россия, Irkutsk
L. Natyaganova
Research Center for Family Health and Human Reproduction Problems
Email: marina_darenskaya@inbox.ru
Россия, Irkutsk
L. Grebenkina
Research Center for Family Health and Human Reproduction Problems
Email: marina_darenskaya@inbox.ru
Россия, Irkutsk
L. Korytov
Irkutsk State Medical University, Ministry of Health of the Russian Federation
Email: marina_darenskaya@inbox.ru
Россия, Irkutsk
S. Kolesnikov
Research Center for Family Health and Human Reproduction Problems; M. V. Lomonosov Moscow State University
Email: marina_darenskaya@inbox.ru
Россия, Irkutsk; Moscow