Behavioral and Cognitive Reactions of Rats with Experimental Chronic Obstructive Lung Diseases of Different Degree
- Authors: Zayats Y.V.1, Kotel’nikov V.N.1,2, Gel’tser B.I.1, Plekhova N.G.1
-
Affiliations:
- School of Biomedicine, Far Eastern Federal University
- Far Eastern Affiliated Branch of the State Research Testing Institute of Military Medicine, Ministry of Defense of Russia
- Issue: Vol 166, No 5 (2019)
- Pages: 602-605
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241222
- DOI: https://doi.org/10.1007/s10517-019-04400-8
- ID: 241222
Cite item
Abstract
The study presents the results of behavioral phenotyping of rats with experimental chronic obstructive pulmonary disease (eCOPD) of different severity modeled by using a combination of inductors (purified papain and bacterial LPS) in increasing concentrations. Locomotor and exploratory activity, spatial memory, and anxiety were evaluated. In mild eCOPD, locomotor and exploratory activity increased, while other parameters did not differ from the control values. Rats with moderate eCOPD demonstrated moderately restricted locomotor function and increased anxiety. Severe eCOPD was associated with pronounced changes in all analyzed parameters. Correlation analysis revealed relationships between some behavioral parameters and blood oxygen saturation, inspiratory lung volume, and respiration rate. This indicates the role of respiratory failure in the pathogenesis of cognitive disorders.
About the authors
Yu. V. Zayats
School of Biomedicine, Far Eastern Federal University
Email: 671235@mail.ru
Russian Federation, Vladivostok
V. N. Kotel’nikov
School of Biomedicine, Far Eastern Federal University; Far Eastern Affiliated Branch of the State Research Testing Institute of Military Medicine, Ministry of Defense of Russia
Author for correspondence.
Email: 671235@mail.ru
Russian Federation, Vladivostok; Vladivostok
B. I. Gel’tser
School of Biomedicine, Far Eastern Federal University
Email: 671235@mail.ru
Russian Federation, Vladivostok
N. G. Plekhova
School of Biomedicine, Far Eastern Federal University
Email: 671235@mail.ru
Russian Federation, Vladivostok
![](/img/style/loading.gif)