Behavioral and Cognitive Reactions of Rats with Experimental Chronic Obstructive Lung Diseases of Different Degree
- 作者: Zayats Y.1, Kotel’nikov V.1,2, Gel’tser B.1, Plekhova N.1
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隶属关系:
- School of Biomedicine, Far Eastern Federal University
- Far Eastern Affiliated Branch of the State Research Testing Institute of Military Medicine, Ministry of Defense of Russia
- 期: 卷 166, 编号 5 (2019)
- 页面: 602-605
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241222
- DOI: https://doi.org/10.1007/s10517-019-04400-8
- ID: 241222
如何引用文章
详细
The study presents the results of behavioral phenotyping of rats with experimental chronic obstructive pulmonary disease (eCOPD) of different severity modeled by using a combination of inductors (purified papain and bacterial LPS) in increasing concentrations. Locomotor and exploratory activity, spatial memory, and anxiety were evaluated. In mild eCOPD, locomotor and exploratory activity increased, while other parameters did not differ from the control values. Rats with moderate eCOPD demonstrated moderately restricted locomotor function and increased anxiety. Severe eCOPD was associated with pronounced changes in all analyzed parameters. Correlation analysis revealed relationships between some behavioral parameters and blood oxygen saturation, inspiratory lung volume, and respiration rate. This indicates the role of respiratory failure in the pathogenesis of cognitive disorders.
作者简介
Yu. Zayats
School of Biomedicine, Far Eastern Federal University
Email: 671235@mail.ru
俄罗斯联邦, Vladivostok
V. Kotel’nikov
School of Biomedicine, Far Eastern Federal University; Far Eastern Affiliated Branch of the State Research Testing Institute of Military Medicine, Ministry of Defense of Russia
编辑信件的主要联系方式.
Email: 671235@mail.ru
俄罗斯联邦, Vladivostok; Vladivostok
B. Gel’tser
School of Biomedicine, Far Eastern Federal University
Email: 671235@mail.ru
俄罗斯联邦, Vladivostok
N. Plekhova
School of Biomedicine, Far Eastern Federal University
Email: 671235@mail.ru
俄罗斯联邦, Vladivostok
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