Effect of Extracellular Vesicles Formed by Multipotent Mesenchymal Stromal Cells on Irradiated Animals
- Authors: Alchinova I.B.1,2, Polyakova M.V.1, Yakovenko E.N.1, Medvedeva Y.S.1, Saburina I.N.1,3, Karganov M.Y.1
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Affiliations:
- Research Institute of General Pathology and Pathophysiology, Ministry of Health of the Russian Federation
- Research Institute for Space Medicine, Federal Research Center of Specialized Health Care and Medical Technologies, Federal Medical-Biological Agency, Ministry of Health of the Russian Federation
- Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation
- Issue: Vol 166, No 4 (2019)
- Pages: 574-579
- Section: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/241202
- DOI: https://doi.org/10.1007/s10517-019-04394-3
- ID: 241202
Cite item
Abstract
C57Bl/6J mice were exposed to γ-radiation in a dose of 7.5 Gy. A week later, the experimental group received intravenous injection of extracellular vesicles isolated from the culture medium of human bone marrow multipotent mesenchymal stromal cells. Changes in the physiological parameters of animals were assessed by laser correlation spectroscopy, histological examination, cytometry, and by differential leukocyte count. In 3 and 6 weeks, the parameters of the experimental group occupied an intermediate position between the intact and irradiated groups or did not differ significantly from the parameters of the intact group. The rate and efficiency of recovery varied at different levels of organization. Reduction of damage caused by irradiation in a sublethal dose at different levels of organization of experimental animals was shown.
About the authors
I. B. Alchinova
Research Institute of General Pathology and Pathophysiology, Ministry of Health of the Russian Federation; Research Institute for Space Medicine, Federal Research Center of Specialized Health Care and Medical Technologies, Federal Medical-Biological Agency, Ministry of Health of the Russian Federation
Email: nedzumy@bk.ru
Russian Federation, Moscow; Moscow
M. V. Polyakova
Research Institute of General Pathology and Pathophysiology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: nedzumy@bk.ru
Russian Federation, Moscow
E. N. Yakovenko
Research Institute of General Pathology and Pathophysiology, Ministry of Health of the Russian Federation
Email: nedzumy@bk.ru
Russian Federation, Moscow
Yu. S. Medvedeva
Research Institute of General Pathology and Pathophysiology, Ministry of Health of the Russian Federation
Email: nedzumy@bk.ru
Russian Federation, Moscow
I. N. Saburina
Research Institute of General Pathology and Pathophysiology, Ministry of Health of the Russian Federation; Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation
Email: nedzumy@bk.ru
Russian Federation, Moscow; Moscow
M. Yu. Karganov
Research Institute of General Pathology and Pathophysiology, Ministry of Health of the Russian Federation
Email: nedzumy@bk.ru
Russian Federation, Moscow