Drug with Neuroprotective Properties Noopept Does Not Stimulate Cell Proliferation
- Authors: Zainullina L.F.1, Ivanova T.V.2, Ostrovskaya R.U.1, Gudasheva T.A.1, Vakhitova Y.V.1, Seredenin S.B.1
-
Affiliations:
- V. V. Zakusov Research Institute of Pharmacology
- Institute of Biochemistry and Genetics, Ufa Federal Research Center of Russian Academy of Sciences
- Issue: Vol 166, No 4 (2019)
- Pages: 466-468
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241108
- DOI: https://doi.org/10.1007/s10517-019-04373-8
- ID: 241108
Cite item
Abstract
Effects of Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) on the relative level of proliferation marker Ki-67 and cell cycle parameters were studied in HEK293 and SH-SY5Y cell lines. The previously established multifactorial mechanism of action of the drug includes enhancement of neurotrophin NGF and BDNF expression and increase in HIF-1 activity. The possible mitogenic action of Noopept was estimated by its effect on cell proliferation. Noopept did not affect cell distribution over G1, S, G2 cell cycle phases and the relative level of proliferation marker Ki-67 in the cell lines under study. These data suggest that Noopept does not stimulate cell growth.
About the authors
L. F. Zainullina
V. V. Zakusov Research Institute of Pharmacology
Email: juvv73@gmail.com
Russian Federation, Moscow
T. V. Ivanova
Institute of Biochemistry and Genetics, Ufa Federal Research Center of Russian Academy of Sciences
Email: juvv73@gmail.com
Russian Federation, Ufa, Republic of Bashkortostan
R. U. Ostrovskaya
V. V. Zakusov Research Institute of Pharmacology
Email: juvv73@gmail.com
Russian Federation, Moscow
T. A. Gudasheva
V. V. Zakusov Research Institute of Pharmacology
Email: juvv73@gmail.com
Russian Federation, Moscow
Yu. V. Vakhitova
V. V. Zakusov Research Institute of Pharmacology
Author for correspondence.
Email: juvv73@gmail.com
Russian Federation, Moscow
S. B. Seredenin
V. V. Zakusov Research Institute of Pharmacology
Email: juvv73@gmail.com
Russian Federation, Moscow