Antioxidant Properties of Glial Cell-Derived Neurotrophic Factor (GDNF)

T. A. Mishchenko; E. V. Mitroshina; T. V. Shishkina; M. B. Vedunova

doi:10.1007/s10517-018-4335-z

Antioxidant Properties of Glial Cell-Derived Neurotrophic Factor (GDNF)

Authors: Mishchenko T.A.¹, Mitroshina E.V.¹, Shishkina T.V.¹, Vedunova M.B.¹
Affiliations:
1. N. I. Lobachevsky Nizhny Novgorod National Research State University
Issue: Vol 166, No 2 (2018)
Pages: 293-296
Section: Methods
URL: https://journals.rcsi.science/0007-4888/article/view/240979
DOI: https://doi.org/10.1007/s10517-018-4335-z
ID: 240979

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Abstract

We propose an in vitro model of chronic oxidative stress based on the use of glucose oxidase. Oxidative stress modeling leads to a significant increase in the number of dead cells in culture. It was shown that the glial cell-derived neurotrophic factor exhibits a pronounced anti-oxidant effect. Preventive application of 1 ng/ml glial cell-derived neurotrophic factor significantly reduced the percentage of dead cells in culture.