Email this article Protective Effect of Polysaccharides from Tussilago farfara L. on Bone Marrow Cells and Small Intestinal Epithelium Under Conditions of Polychemotherapy Evaluated by DNA Comet Assay
- Authors: Safonova E.A.1, Lopatina K.A.1, Vychuzhanina A.V.1, Mashanova V.A.1, Razina T.G.1, Borovskaya T.G.1, Zueva E.P.1, Gur’ev A.M.2, Belousov M.V.2
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Affiliations:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- Siberian State Medical University of Ministry of Health of Russian Federation
- Issue: Vol 166, No 2 (2018)
- Pages: 217-221
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240914
- DOI: https://doi.org/10.1007/s10517-018-4317-1
- ID: 240914
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Abstract
Using DNA comet assay we found that polysaccharides from Tussilago farfara L. reduced the intensity of polychemotherapy-induced apoptosis and DNA damage in bone marrow cells and small intestinal epithelium of C57Bl/6 mice, which attested to genoprotective properties of these polysaccharides.
About the authors
E. A. Safonova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Author for correspondence.
Email: safonova_7@mail.ru
Russian Federation, Tomsk
K. A. Lopatina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: safonova_7@mail.ru
Russian Federation, Tomsk
A. V. Vychuzhanina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: safonova_7@mail.ru
Russian Federation, Tomsk
V. A. Mashanova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: safonova_7@mail.ru
Russian Federation, Tomsk
T. G. Razina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: safonova_7@mail.ru
Russian Federation, Tomsk
T. G. Borovskaya
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: safonova_7@mail.ru
Russian Federation, Tomsk
E. P. Zueva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: safonova_7@mail.ru
Russian Federation, Tomsk
A. M. Gur’ev
Siberian State Medical University of Ministry of Health of Russian Federation
Email: safonova_7@mail.ru
Russian Federation, Tomsk
M. V. Belousov
Siberian State Medical University of Ministry of Health of Russian Federation
Email: safonova_7@mail.ru
Russian Federation, Tomsk
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