Protective Effect of Polysaccharides from  Tussilago farfara  L .  on Bone Marrow Cells and Small Intestinal Epithelium Under Conditions of Polychemotherapy Evaluated by DNA Comet Assay

E. A. Safonova; K. A. Lopatina; A. V. Vychuzhanina; V. A. Mashanova; T. G. Razina; T. G. Borovskaya; E. P. Zueva; A. M. Gur’ev; M. V. Belousov

doi:10.1007/s10517-018-4317-1

Protective Effect of Polysaccharides from Tussilago farfara L. on Bone Marrow Cells and Small Intestinal Epithelium Under Conditions of Polychemotherapy Evaluated by DNA Comet Assay

Autores: Safonova E.¹, Lopatina K.¹, Vychuzhanina A.¹, Mashanova V.¹, Razina T.¹, Borovskaya T.¹, Zueva E.¹, Gur’ev A.², Belousov M.²
Afiliações:
1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
2. Siberian State Medical University of Ministry of Health of Russian Federation
Edição: Volume 166, Nº 2 (2018)
Páginas: 217-221
Seção: Article
URL: https://journals.rcsi.science/0007-4888/article/view/240914
DOI: https://doi.org/10.1007/s10517-018-4317-1
ID: 240914

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Using DNA comet assay we found that polysaccharides from Tussilago farfara L. reduced the intensity of polychemotherapy-induced apoptosis and DNA damage in bone marrow cells and small intestinal epithelium of C57Bl/6 mice, which attested to genoprotective properties of these polysaccharides.