Biochemical and Morphological Parameters of Inbred/Outbred Lines and DBCB Tetrahybrid Mouse in High-Sugar In Vivo Model of Metabolic Syndrome
- Authors: Apryatin S.A.1, Mzhel’skaya K.V.1, Trusov N.V.1, Balakina A.S.1, Soto K.S.1, Beketova N.A.1, Kosheleva O.V.1, Gmoshinskii I.V.1, Nikityuk D.B.1
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Affiliations:
- Federal Research Center of Nutrition and Biotechnology
- Issue: Vol 166, No 1 (2018)
- Pages: 96-101
- Section: Morphology and Pathomorphology
- URL: https://journals.rcsi.science/0007-4888/article/view/240855
- DOI: https://doi.org/10.1007/s10517-018-4296-2
- ID: 240855
Cite item
Abstract
Integral, biochemical, and morphological parameters and concentrations of vitamins, particularly lipid soluble vitamins, were analyzed in female mice of inbred DBA/2J line, outbred ICR-1 (CD-1) line, and DBCB tetrahybrid mice on the in vivo model of metabolic syndrome induced by consumption of 30% sucrose for 2 days. In contrast to inbred and outbred lines, DBCB tetrahybrid mice developed abdominal obesity, hypercholesterolemia, and pronounced morphological picture of fatty liver disease. The lipid-coupled transport of vitamin E to the liver is also enhanced in these animals, which compensated decreased supply of vitamin E to the liver under conditions of high-sugar ration. The observed interstrain differences can be related to genetic features of the used mouse lines and DBCB tetrahybrid mice and require further genomic, transcriptomic, proteomic, and morphological studies. The results of the study based on the in vivo model of metabolic syndrome allow identifying the key biomarkers for complex diagnostics and prognosis of metabolic syndrome complications, such as nonalcoholic steatosis of the liver.
About the authors
S. A. Apryatin
Federal Research Center of Nutrition and Biotechnology
Author for correspondence.
Email: apryatin@mail.ru
Russian Federation, Moscow
K. V. Mzhel’skaya
Federal Research Center of Nutrition and Biotechnology
Email: apryatin@mail.ru
Russian Federation, Moscow
N. V. Trusov
Federal Research Center of Nutrition and Biotechnology
Email: apryatin@mail.ru
Russian Federation, Moscow
A. S. Balakina
Federal Research Center of Nutrition and Biotechnology
Email: apryatin@mail.ru
Russian Federation, Moscow
Kh. S. Soto
Federal Research Center of Nutrition and Biotechnology
Email: apryatin@mail.ru
Russian Federation, Moscow
N. A. Beketova
Federal Research Center of Nutrition and Biotechnology
Email: apryatin@mail.ru
Russian Federation, Moscow
O. V. Kosheleva
Federal Research Center of Nutrition and Biotechnology
Email: apryatin@mail.ru
Russian Federation, Moscow
I. V. Gmoshinskii
Federal Research Center of Nutrition and Biotechnology
Email: apryatin@mail.ru
Russian Federation, Moscow
D. B. Nikityuk
Federal Research Center of Nutrition and Biotechnology
Email: apryatin@mail.ru
Russian Federation, Moscow
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