Biochemical and Morphological Parameters of Inbred/Outbred Lines and DBCB Tetrahybrid Mouse in High-Sugar In Vivo Model of Metabolic Syndrome
- 作者: Apryatin S.1, Mzhel’skaya K.1, Trusov N.1, Balakina A.1, Soto K.1, Beketova N.1, Kosheleva O.1, Gmoshinskii I.1, Nikityuk D.1
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隶属关系:
- Federal Research Center of Nutrition and Biotechnology
- 期: 卷 166, 编号 1 (2018)
- 页面: 96-101
- 栏目: Morphology and Pathomorphology
- URL: https://journals.rcsi.science/0007-4888/article/view/240855
- DOI: https://doi.org/10.1007/s10517-018-4296-2
- ID: 240855
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详细
Integral, biochemical, and morphological parameters and concentrations of vitamins, particularly lipid soluble vitamins, were analyzed in female mice of inbred DBA/2J line, outbred ICR-1 (CD-1) line, and DBCB tetrahybrid mice on the in vivo model of metabolic syndrome induced by consumption of 30% sucrose for 2 days. In contrast to inbred and outbred lines, DBCB tetrahybrid mice developed abdominal obesity, hypercholesterolemia, and pronounced morphological picture of fatty liver disease. The lipid-coupled transport of vitamin E to the liver is also enhanced in these animals, which compensated decreased supply of vitamin E to the liver under conditions of high-sugar ration. The observed interstrain differences can be related to genetic features of the used mouse lines and DBCB tetrahybrid mice and require further genomic, transcriptomic, proteomic, and morphological studies. The results of the study based on the in vivo model of metabolic syndrome allow identifying the key biomarkers for complex diagnostics and prognosis of metabolic syndrome complications, such as nonalcoholic steatosis of the liver.
作者简介
S. Apryatin
Federal Research Center of Nutrition and Biotechnology
编辑信件的主要联系方式.
Email: apryatin@mail.ru
俄罗斯联邦, Moscow
K. Mzhel’skaya
Federal Research Center of Nutrition and Biotechnology
Email: apryatin@mail.ru
俄罗斯联邦, Moscow
N. Trusov
Federal Research Center of Nutrition and Biotechnology
Email: apryatin@mail.ru
俄罗斯联邦, Moscow
A. Balakina
Federal Research Center of Nutrition and Biotechnology
Email: apryatin@mail.ru
俄罗斯联邦, Moscow
Kh. Soto
Federal Research Center of Nutrition and Biotechnology
Email: apryatin@mail.ru
俄罗斯联邦, Moscow
N. Beketova
Federal Research Center of Nutrition and Biotechnology
Email: apryatin@mail.ru
俄罗斯联邦, Moscow
O. Kosheleva
Federal Research Center of Nutrition and Biotechnology
Email: apryatin@mail.ru
俄罗斯联邦, Moscow
I. Gmoshinskii
Federal Research Center of Nutrition and Biotechnology
Email: apryatin@mail.ru
俄罗斯联邦, Moscow
D. Nikityuk
Federal Research Center of Nutrition and Biotechnology
Email: apryatin@mail.ru
俄罗斯联邦, Moscow
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