Email this article Antioxidant Properties of a Pharmaceutical Substance Hypocard, a Potential Drug for Ischemic Disease
- Authors: Neganova M.E.1, Klochkov S.G.1, Shevtsova E.F.1, Bogatyrenko T.N.2, Mishchenko D.V.2,3
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Affiliations:
- Institute of Physiologically Active Substances, Russian Academy of Sciences
- Institute of Problems of Chemical Physics, Russian Academy of Sciences
- Medical Chemistry Research and Educational Center, Moscow State Regional University
- Issue: Vol 166, No 1 (2018)
- Pages: 46-49
- Section: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/240822
- DOI: https://doi.org/10.1007/s10517-018-4286-4
- ID: 240822
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Abstract
Antioxidant activity of a pharmaceutical substance hypocard was compared with activity of nitromalic acid and well-known agents nicorandil and Mexidol. The ability of these substances to inhibit spontaneous and oxidant-induced LPO process in rat brain homogenate was analyzed. The mechanisms of these effects were studied. The antioxidant properties of hypocard manifested in the inhibition of Fe(II)-induced LPO were significantly more pronounced in comparison with Mexidol and nicorandil.
About the authors
M. E. Neganova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Author for correspondence.
Email: neganova83@mail.ru
Russian Federation, Moscow
S. G. Klochkov
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
Russian Federation, Moscow
E. F. Shevtsova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
Russian Federation, Moscow
T. N. Bogatyrenko
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: neganova83@mail.ru
Russian Federation, Moscow
D. V. Mishchenko
Institute of Problems of Chemical Physics, Russian Academy of Sciences; Medical Chemistry Research and Educational Center, Moscow State Regional University
Email: neganova83@mail.ru
Russian Federation, Moscow; Chernogolovka
