Enviar artigo por via de e-mail Antioxidant Properties of a Pharmaceutical Substance Hypocard, a Potential Drug for Ischemic Disease
- Autores: Neganova M.1, Klochkov S.1, Shevtsova E.1, Bogatyrenko T.2, Mishchenko D.2,3
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Afiliações:
- Institute of Physiologically Active Substances, Russian Academy of Sciences
- Institute of Problems of Chemical Physics, Russian Academy of Sciences
- Medical Chemistry Research and Educational Center, Moscow State Regional University
- Edição: Volume 166, Nº 1 (2018)
- Páginas: 46-49
- Seção: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/240822
- DOI: https://doi.org/10.1007/s10517-018-4286-4
- ID: 240822
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Resumo
Antioxidant activity of a pharmaceutical substance hypocard was compared with activity of nitromalic acid and well-known agents nicorandil and Mexidol. The ability of these substances to inhibit spontaneous and oxidant-induced LPO process in rat brain homogenate was analyzed. The mechanisms of these effects were studied. The antioxidant properties of hypocard manifested in the inhibition of Fe(II)-induced LPO were significantly more pronounced in comparison with Mexidol and nicorandil.
Sobre autores
M. Neganova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Autor responsável pela correspondência
Email: neganova83@mail.ru
Rússia, Moscow
S. Klochkov
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
Rússia, Moscow
E. Shevtsova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
Rússia, Moscow
T. Bogatyrenko
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: neganova83@mail.ru
Rússia, Moscow
D. Mishchenko
Institute of Problems of Chemical Physics, Russian Academy of Sciences; Medical Chemistry Research and Educational Center, Moscow State Regional University
Email: neganova83@mail.ru
Rússia, Moscow; Chernogolovka
