Email this article Neuroprotective Effects of Dibornol in Focal Cerebral Ischemia/Reperfusion in Rats
- Authors: Chenysheva G.A.1, Smol’akova V.A.1, Kutchin A.V.2, Chukicheva I.Y.2, Plotnikov M.B.1
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Affiliations:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
- Issue: Vol 166, No 1 (2018)
- Pages: 15-18
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240796
- DOI: https://doi.org/10.1007/s10517-018-4278-4
- ID: 240796
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Abstract
Neuroprotective activity of 2,6-diisobornyl-4-methylphenol (Dibornol) was studied under conditions of experimental focal cerebral ischemia/reperfusion modeled by intraluminal occlusion of the left middle cerebral artery for 1 h followed by recirculation. Dibornol administered in a dose of 10 mg/kg intragastrically 24 h and 30 min before and 24 h after focal ischemia/reperfusion modeling reduced the size of the brain infarction zone by 52% (48 h after recirculation) and neurological deficit by 1.7-2.4 times in comparison with that in control animals.
About the authors
G. A. Chenysheva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: mbp2001@mail.ru
Russian Federation, Tomsk
V. A. Smol’akova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: mbp2001@mail.ru
Russian Federation, Tomsk
A. V. Kutchin
Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
Email: mbp2001@mail.ru
Russian Federation, Syktyvkar
I. Yu. Chukicheva
Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
Email: mbp2001@mail.ru
Russian Federation, Syktyvkar
M. B. Plotnikov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Author for correspondence.
Email: mbp2001@mail.ru
Russian Federation, Tomsk
