Neuroprotective Effects of Dibornol in Focal Cerebral Ischemia/Reperfusion in Rats
- Autores: Chenysheva G.1, Smol’akova V.1, Kutchin A.2, Chukicheva I.2, Plotnikov M.1
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Afiliações:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
- Edição: Volume 166, Nº 1 (2018)
- Páginas: 15-18
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240796
- DOI: https://doi.org/10.1007/s10517-018-4278-4
- ID: 240796
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Resumo
Neuroprotective activity of 2,6-diisobornyl-4-methylphenol (Dibornol) was studied under conditions of experimental focal cerebral ischemia/reperfusion modeled by intraluminal occlusion of the left middle cerebral artery for 1 h followed by recirculation. Dibornol administered in a dose of 10 mg/kg intragastrically 24 h and 30 min before and 24 h after focal ischemia/reperfusion modeling reduced the size of the brain infarction zone by 52% (48 h after recirculation) and neurological deficit by 1.7-2.4 times in comparison with that in control animals.
Sobre autores
G. Chenysheva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: mbp2001@mail.ru
Rússia, Tomsk
V. Smol’akova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: mbp2001@mail.ru
Rússia, Tomsk
A. Kutchin
Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
Email: mbp2001@mail.ru
Rússia, Syktyvkar
I. Chukicheva
Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
Email: mbp2001@mail.ru
Rússia, Syktyvkar
M. Plotnikov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Autor responsável pela correspondência
Email: mbp2001@mail.ru
Rússia, Tomsk
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