Email this article Experimental Study of the Effectiveness of Phenolic Antioxidants in Male Infertility Caused by Pathospermia
- Authors: Borovskaya T.G.1, Kamalova S.I.1, Krivova N.A.2, Zaeva O.B.2, Poluektova M.E.1, Vychuzhanina A.V.1, Grigor’eva V.A.1, Plotnikov M.B.1, Goldberg V.E.3
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Affiliations:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- Research Institute of Biology and Biophysics, National Research Tomsk State University
- Research Institute of Oncology, Tomsk National Research Medical Center, Russian Academy of Sciences
- Issue: Vol 166, No 1 (2018)
- Pages: 7-10
- Section: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/240792
- DOI: https://doi.org/10.1007/s10517-018-4276-6
- ID: 240792
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Abstract
The effect of phenolic antioxidants (dihydroquercetin, p-tyrosol, dibornol) on the morphology, functions, and redox processes in the reproductive cells of male rats was studied on the model of experimental pathospermia. All antioxidants reduced the percentage of degenerative forms of spermatozoa. Dibornol was most effective. Dihydroquercetin and p-tyrosol did not increase the total number of spermatozoa and the percentage of their mobile forms. These indicators were improved only by dibornol. After administration of all test drugs, the antioxidant potential of spermatozoa increased and did not significantly differ from the baseline values.
About the authors
T. G. Borovskaya
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Author for correspondence.
Email: repropharm@yandex.ru
Russian Federation, Tomsk
S. I. Kamalova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Russian Federation, Tomsk
N. A. Krivova
Research Institute of Biology and Biophysics, National Research Tomsk State University
Email: repropharm@yandex.ru
Russian Federation, Tomsk
O. B. Zaeva
Research Institute of Biology and Biophysics, National Research Tomsk State University
Email: repropharm@yandex.ru
Russian Federation, Tomsk
M. E. Poluektova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Russian Federation, Tomsk
A. V. Vychuzhanina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Russian Federation, Tomsk
V. A. Grigor’eva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Russian Federation, Tomsk
M. B. Plotnikov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Russian Federation, Tomsk
V. E. Goldberg
Research Institute of Oncology, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Russian Federation, Tomsk
