Experimental Study of the Effectiveness of Phenolic Antioxidants in Male Infertility Caused by Pathospermia


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The effect of phenolic antioxidants (dihydroquercetin, p-tyrosol, dibornol) on the morphology, functions, and redox processes in the reproductive cells of male rats was studied on the model of experimental pathospermia. All antioxidants reduced the percentage of degenerative forms of spermatozoa. Dibornol was most effective. Dihydroquercetin and p-tyrosol did not increase the total number of spermatozoa and the percentage of their mobile forms. These indicators were improved only by dibornol. After administration of all test drugs, the antioxidant potential of spermatozoa increased and did not significantly differ from the baseline values.

作者简介

T. Borovskaya

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

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俄罗斯联邦, Tomsk

S. Kamalova

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

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俄罗斯联邦, Tomsk

N. Krivova

Research Institute of Biology and Biophysics, National Research Tomsk State University

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俄罗斯联邦, Tomsk

O. Zaeva

Research Institute of Biology and Biophysics, National Research Tomsk State University

Email: repropharm@yandex.ru
俄罗斯联邦, Tomsk

M. Poluektova

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: repropharm@yandex.ru
俄罗斯联邦, Tomsk

A. Vychuzhanina

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: repropharm@yandex.ru
俄罗斯联邦, Tomsk

V. Grigor’eva

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: repropharm@yandex.ru
俄罗斯联邦, Tomsk

M. Plotnikov

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: repropharm@yandex.ru
俄罗斯联邦, Tomsk

V. Goldberg

Research Institute of Oncology, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: repropharm@yandex.ru
俄罗斯联邦, Tomsk


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