Email this article Expression of microRNA Potentially Regulated by AhR and CAR in Malignant Tumors of the Endometrium
- Authors: Ushakov D.S.1, Dorozhkova A.S.1, Babayants E.V.1, Ovchinnikov V.Y.2, Kushlinskii D.N.3, Adamyan L.V.3, Gulyaeva L.F.2, Kushlinskii N.E.4
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Affiliations:
- Research Institute of Molecular Biology and Biophysics
- Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- V. I. Kulakov National Research Medical Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation
- Issue: Vol 165, No 5 (2018)
- Pages: 688-691
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240668
- DOI: https://doi.org/10.1007/s10517-018-4242-3
- ID: 240668
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Abstract
We studied microRNA whose expression can be regulated by carcinogenic compounds. Bioinformatic analysis has detected microRNA potentially regulated by xenosensor receptors AhR (miR-28, miR-30c, miR-30e, miR-139, and miR-153) and CAR (miR-29c, miR-31, miR-185, miR-625, and miR-652). Published data indicate that these microRNAs are oncosuppressors, except miR-31 that can act as an oncogene. The expression of these microRNAs in malignant tumors of the endometrium was studied. The expression of the majority of the studied microRNAs, except miR-652, was 2-3-fold below the normal, which confirms their oncosuppressor function and indicates their involvement in the endometrial carcinogenesis and hence, allows considering them as potential markers of the disease.
About the authors
D. S. Ushakov
Research Institute of Molecular Biology and Biophysics
Author for correspondence.
Email: d.ushackov@gmail.com
Russian Federation, Novosibirsk
A. S. Dorozhkova
Research Institute of Molecular Biology and Biophysics
Email: d.ushackov@gmail.com
Russian Federation, Novosibirsk
E. V. Babayants
Research Institute of Molecular Biology and Biophysics
Email: d.ushackov@gmail.com
Russian Federation, Novosibirsk
V. Yu. Ovchinnikov
Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: d.ushackov@gmail.com
Russian Federation, Novosibirsk
D. N. Kushlinskii
V. I. Kulakov National Research Medical Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: d.ushackov@gmail.com
Russian Federation, Moscow
L. V. Adamyan
V. I. Kulakov National Research Medical Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: d.ushackov@gmail.com
Russian Federation, Moscow
L. F. Gulyaeva
Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: d.ushackov@gmail.com
Russian Federation, Novosibirsk
N. E. Kushlinskii
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation
Email: d.ushackov@gmail.com
Russian Federation, Moscow
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