Expression of microRNA Potentially Regulated by AhR and CAR in Malignant Tumors of the Endometrium
- Авторлар: Ushakov D.1, Dorozhkova A.1, Babayants E.1, Ovchinnikov V.2, Kushlinskii D.3, Adamyan L.3, Gulyaeva L.2, Kushlinskii N.4
-
Мекемелер:
- Research Institute of Molecular Biology and Biophysics
- Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- V. I. Kulakov National Research Medical Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation
- Шығарылым: Том 165, № 5 (2018)
- Беттер: 688-691
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240668
- DOI: https://doi.org/10.1007/s10517-018-4242-3
- ID: 240668
Дәйексөз келтіру
Аннотация
We studied microRNA whose expression can be regulated by carcinogenic compounds. Bioinformatic analysis has detected microRNA potentially regulated by xenosensor receptors AhR (miR-28, miR-30c, miR-30e, miR-139, and miR-153) and CAR (miR-29c, miR-31, miR-185, miR-625, and miR-652). Published data indicate that these microRNAs are oncosuppressors, except miR-31 that can act as an oncogene. The expression of these microRNAs in malignant tumors of the endometrium was studied. The expression of the majority of the studied microRNAs, except miR-652, was 2-3-fold below the normal, which confirms their oncosuppressor function and indicates their involvement in the endometrial carcinogenesis and hence, allows considering them as potential markers of the disease.
Авторлар туралы
D. Ushakov
Research Institute of Molecular Biology and Biophysics
Хат алмасуға жауапты Автор.
Email: d.ushackov@gmail.com
Ресей, Novosibirsk
A. Dorozhkova
Research Institute of Molecular Biology and Biophysics
Email: d.ushackov@gmail.com
Ресей, Novosibirsk
E. Babayants
Research Institute of Molecular Biology and Biophysics
Email: d.ushackov@gmail.com
Ресей, Novosibirsk
V. Ovchinnikov
Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: d.ushackov@gmail.com
Ресей, Novosibirsk
D. Kushlinskii
V. I. Kulakov National Research Medical Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: d.ushackov@gmail.com
Ресей, Moscow
L. Adamyan
V. I. Kulakov National Research Medical Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: d.ushackov@gmail.com
Ресей, Moscow
L. Gulyaeva
Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: d.ushackov@gmail.com
Ресей, Novosibirsk
N. Kushlinskii
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation
Email: d.ushackov@gmail.com
Ресей, Moscow