Evaluation of Regenerative Potential of Cryopreserved Adenosine-Modified Monocytes on the Model of Burn Wounds

K. V. Nevskaya; V. V. Ivanov; E. S. Mainagasheva; S. S. Gutor; S. P. Lezhava; A. E. Sazonov

doi:10.1007/s10517-018-4209-4

Evaluation of Regenerative Potential of Cryopreserved Adenosine-Modified Monocytes on the Model of Burn Wounds

Authors: Nevskaya K.V.¹, Ivanov V.V.¹, Mainagasheva E.S.¹, Gutor S.S.¹, Lezhava S.P.¹, Sazonov A.E.¹^,2
Affiliations:
1. Siberian State Medical University, Ministry of Health of the Russian Federation
2. D. I. Mendeleev University of Chemical Technology
Issue: Vol 165, No 4 (2018)
Pages: 526-529
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/240486
DOI: https://doi.org/10.1007/s10517-018-4209-4
ID: 240486

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Abstract

We studied viability of adenosine-modified monocytes after cryopreservation and their regenerative potential. The optimal method of cell cryopreservation was the use of serum-free medium followed by storage in liquid nitrogen. Injections of adenosine-modified monocytes after 12-week cryopreservation around grade IIIB burn wound accelerated healing of the skin defect and significantly improved the histological pattern of the damage area at delayed terms.