Email this article Pathogenetic Role of Endothelial Dysfunction in Idiopathic Vestibulopathy
- Authors: Udut E.V.1,2, Shchetinin P.P.1, Rudenko T.V.1, Lucieer F.3, Kingma H.1,3, Shchetinina A.P.1, Pleshkov M.O.1, Demkin V.P.1, Udut V.V.1,2
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Affiliations:
- National Research Tomsk State University
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- Department of Otorhinolaryngology and Head and Neck Surgery, Division of Balance Disorders, Faculty of Health Medicine and Life Sciences, Maastricht University Medical Center, School for Mental Health and Neuroscience
- Issue: Vol 164, No 6 (2018)
- Pages: 726-729
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239881
- DOI: https://doi.org/10.1007/s10517-018-4067-0
- ID: 239881
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Abstract
Comparative analysis of the groups of patients with idiopathic bilateral vestibular hypofunction and a group of vestibulopathy patients with vertebrobasilar insufficiency demonstrated identity of the basic and additional diagnostic parameters in these syndromes as well as similarity in clinical diagnostic and anamnesis data. In all cases, functional assessment of endothelium-dependent vasodilation and selected biochemical marker sICAM-1 revealed endothelial dysfunction. Drug correction of endothelial dysfunction positively affected the manifestations of major and minor features of the syndrome, which confirmed the contribution of endothelial functional disturbances to the pathogenesis of bilateral vestibular hypofunction.
About the authors
E. V. Udut
National Research Tomsk State University; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Author for correspondence.
Email: evu8@mail.ru
Russian Federation, Tomsk; Tomsk
P. P. Shchetinin
National Research Tomsk State University
Email: evu8@mail.ru
Russian Federation, Tomsk
T. V. Rudenko
National Research Tomsk State University
Email: evu8@mail.ru
Russian Federation, Tomsk
F. Lucieer
Department of Otorhinolaryngology and Head and Neck Surgery, Division of Balance Disorders, Faculty of Health Medicine and Life Sciences, Maastricht University Medical Center, School for Mental Health and Neuroscience
Email: evu8@mail.ru
Netherlands, Maastricht
H. Kingma
National Research Tomsk State University; Department of Otorhinolaryngology and Head and Neck Surgery, Division of Balance Disorders, Faculty of Health Medicine and Life Sciences, Maastricht University Medical Center, School for Mental Health and Neuroscience
Email: evu8@mail.ru
Russian Federation, Tomsk; Maastricht
A. P. Shchetinina
National Research Tomsk State University
Email: evu8@mail.ru
Russian Federation, Tomsk
M. O. Pleshkov
National Research Tomsk State University
Email: evu8@mail.ru
Russian Federation, Tomsk
V. P. Demkin
National Research Tomsk State University
Email: evu8@mail.ru
Russian Federation, Tomsk
V. V. Udut
National Research Tomsk State University; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: evu8@mail.ru
Russian Federation, Tomsk; Tomsk
