Pathogenetic Role of Endothelial Dysfunction in Idiopathic Vestibulopathy
- 作者: Udut E.1,2, Shchetinin P.1, Rudenko T.1, Lucieer F.3, Kingma H.1,3, Shchetinina A.1, Pleshkov M.1, Demkin V.1, Udut V.1,2
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隶属关系:
- National Research Tomsk State University
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- Department of Otorhinolaryngology and Head and Neck Surgery, Division of Balance Disorders, Faculty of Health Medicine and Life Sciences, Maastricht University Medical Center, School for Mental Health and Neuroscience
- 期: 卷 164, 编号 6 (2018)
- 页面: 726-729
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239881
- DOI: https://doi.org/10.1007/s10517-018-4067-0
- ID: 239881
如何引用文章
详细
Comparative analysis of the groups of patients with idiopathic bilateral vestibular hypofunction and a group of vestibulopathy patients with vertebrobasilar insufficiency demonstrated identity of the basic and additional diagnostic parameters in these syndromes as well as similarity in clinical diagnostic and anamnesis data. In all cases, functional assessment of endothelium-dependent vasodilation and selected biochemical marker sICAM-1 revealed endothelial dysfunction. Drug correction of endothelial dysfunction positively affected the manifestations of major and minor features of the syndrome, which confirmed the contribution of endothelial functional disturbances to the pathogenesis of bilateral vestibular hypofunction.
作者简介
E. Udut
National Research Tomsk State University; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: evu8@mail.ru
俄罗斯联邦, Tomsk; Tomsk
P. Shchetinin
National Research Tomsk State University
Email: evu8@mail.ru
俄罗斯联邦, Tomsk
T. Rudenko
National Research Tomsk State University
Email: evu8@mail.ru
俄罗斯联邦, Tomsk
F. Lucieer
Department of Otorhinolaryngology and Head and Neck Surgery, Division of Balance Disorders, Faculty of Health Medicine and Life Sciences, Maastricht University Medical Center, School for Mental Health and Neuroscience
Email: evu8@mail.ru
荷兰, Maastricht
H. Kingma
National Research Tomsk State University; Department of Otorhinolaryngology and Head and Neck Surgery, Division of Balance Disorders, Faculty of Health Medicine and Life Sciences, Maastricht University Medical Center, School for Mental Health and Neuroscience
Email: evu8@mail.ru
俄罗斯联邦, Tomsk; Maastricht
A. Shchetinina
National Research Tomsk State University
Email: evu8@mail.ru
俄罗斯联邦, Tomsk
M. Pleshkov
National Research Tomsk State University
Email: evu8@mail.ru
俄罗斯联邦, Tomsk
V. Demkin
National Research Tomsk State University
Email: evu8@mail.ru
俄罗斯联邦, Tomsk
V. Udut
National Research Tomsk State University; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: evu8@mail.ru
俄罗斯联邦, Tomsk; Tomsk
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