Email this article Compounds of IL-6 Receptor Complex during Acute Lung Injury
- Authors: Chepurnova D.A.1, Samoilova E.V.1, Anisimov A.A.1, Verin A.D.2, Korotaeva A.A.1
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Affiliations:
- National Medical Research Center of Сardiology, Ministry of Healthcare of the Russian Federation
- Augusta University
- Issue: Vol 164, No 5 (2018)
- Pages: 609-611
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239782
- DOI: https://doi.org/10.1007/s10517-018-4042-9
- ID: 239782
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Abstract
Soluble receptor of IL-6 (sIL-6R) and antagonist of the receptor complex, soluble glycoprotein 130 (sgp130) mediate opposite effects during inflammation. We measured the levels of these cytokines and their ratio in rat blood on the model of acute lung injury. The injury was modeled by the intratracheal administration of LPS. The levels of sgp130 and sIL-6R increased during the inflammatory process in the injured lungs. The sgp130/sIL-6R ratio increased or decreased depending on the intensity of the inflammatory process. sgp130/sIL-6R ratio might reflect the intensity of inflammation during lung injury.
About the authors
D. A. Chepurnova
National Medical Research Center of Сardiology, Ministry of Healthcare of the Russian Federation
Author for correspondence.
Email: dchepurnova@gmail.com
Russian Federation, Moscow
E. V. Samoilova
National Medical Research Center of Сardiology, Ministry of Healthcare of the Russian Federation
Email: dchepurnova@gmail.com
Russian Federation, Moscow
A. A. Anisimov
National Medical Research Center of Сardiology, Ministry of Healthcare of the Russian Federation
Email: dchepurnova@gmail.com
Russian Federation, Moscow
A. D. Verin
Augusta University
Email: dchepurnova@gmail.com
United States, Augusta, GA
A. A. Korotaeva
National Medical Research Center of Сardiology, Ministry of Healthcare of the Russian Federation
Email: dchepurnova@gmail.com
Russian Federation, Moscow
