Отправить статью по E-mail Compounds of IL-6 Receptor Complex during Acute Lung Injury
- Авторы: Chepurnova D.A.1, Samoilova E.V.1, Anisimov A.A.1, Verin A.D.2, Korotaeva A.A.1
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Учреждения:
- National Medical Research Center of Сardiology, Ministry of Healthcare of the Russian Federation
- Augusta University
- Выпуск: Том 164, № 5 (2018)
- Страницы: 609-611
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239782
- DOI: https://doi.org/10.1007/s10517-018-4042-9
- ID: 239782
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Аннотация
Soluble receptor of IL-6 (sIL-6R) and antagonist of the receptor complex, soluble glycoprotein 130 (sgp130) mediate opposite effects during inflammation. We measured the levels of these cytokines and their ratio in rat blood on the model of acute lung injury. The injury was modeled by the intratracheal administration of LPS. The levels of sgp130 and sIL-6R increased during the inflammatory process in the injured lungs. The sgp130/sIL-6R ratio increased or decreased depending on the intensity of the inflammatory process. sgp130/sIL-6R ratio might reflect the intensity of inflammation during lung injury.
Об авторах
D. Chepurnova
National Medical Research Center of Сardiology, Ministry of Healthcare of the Russian Federation
Автор, ответственный за переписку.
Email: dchepurnova@gmail.com
Россия, Moscow
E. Samoilova
National Medical Research Center of Сardiology, Ministry of Healthcare of the Russian Federation
Email: dchepurnova@gmail.com
Россия, Moscow
A. Anisimov
National Medical Research Center of Сardiology, Ministry of Healthcare of the Russian Federation
Email: dchepurnova@gmail.com
Россия, Moscow
A. Verin
Augusta University
Email: dchepurnova@gmail.com
США, Augusta, GA
A. Korotaeva
National Medical Research Center of Сardiology, Ministry of Healthcare of the Russian Federation
Email: dchepurnova@gmail.com
Россия, Moscow
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