Survival of Mesenchymal Stem Cells in Different Methods of Nebulization

A. V. Aver’yanov; A. G. Konoplyannikov; N. S. Antonov; G. L. Osipova; O. S. Vasil’eva; M. G. Sakharova; A. R. Tatarskii; V. I. Kobylyansky

doi:10.1007/s10517-018-4034-9

Survival of Mesenchymal Stem Cells in Different Methods of Nebulization

Authors: Aver’yanov A.V.¹, Konoplyannikov A.G.², Antonov N.S.¹, Osipova G.L.¹, Vasil’eva O.S.¹, Sakharova M.G.¹, Tatarskii A.R.¹, Kobylyansky V.I.¹
Affiliations:
1. Research Institute of Pulmonology, Federal Biomedical Agency
2. National Medical Radiology Research Center, Ministry of Health of the Russian Federation
Issue: Vol 164, No 4 (2018)
Pages: 576-578
Section: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
URL: https://journals.rcsi.science/0007-4888/article/view/239754
DOI: https://doi.org/10.1007/s10517-018-4034-9
ID: 239754

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Abstract

We compared survival of bone marrow mesenchymal stem cells after compressor, ultrasound, and mesh nebulization of the cell suspension over 10 min. Viability of stromal cells was best preserved after compressor nebulization (72%). Cell survival after ultrasonic nebulization was significantly lower (20%). After mesh nebulization, no live cells were found. Thus, compressor nebulization is the most preferable method of the production of cell aerosol for their delivery to the lower respiratory tract.

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Survival of Mesenchymal Stem Cells in Different Methods of Nebulization

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Abstract

About the authors

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