Morphological Evaluation of the Influence of the Peptide Complex from Tissue of Porcine Kidneys on the Experimental Urolithiasis

A. Yu. Zharikov; V. I. Kiselev; I. P. Saldan; G. V. Zharikova; A. V. Lepilov; I. P. Bobrov

doi:10.1007/s10517-017-3959-8

Morphological Evaluation of the Influence of the Peptide Complex from Tissue of Porcine Kidneys on the Experimental Urolithiasis

Authors: Zharikov A.Y.¹, Kiselev V.I.¹, Saldan I.P.¹, Zharikova G.V.¹, Lepilov A.V.¹, Bobrov I.P.¹
Affiliations:
1. Altai State Medical University, Ministry of Health of the Russian Federation
Issue: Vol 164, No 2 (2017)
Pages: 207-210
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/239495
DOI: https://doi.org/10.1007/s10517-017-3959-8
ID: 239495

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Abstract

We performed morphological analysis of the effect of the peptide complex from porcine kidneys on the course of experimental urolithiasis modeled in rats by treatment with 1% ethylene glycol solution (in drinking water) for 6 weeks. The peptide complex obtained by acetic acid extraction was administered in a dose of 15 mg. Administration of the peptide complex to animals with experimental kidney stone disease leads to 100% destruction of large and medium stones to the “dust” granularity.