Email this article Behavior Disorders Caused by Perinatal Hypoxia in Juvenile Rats and Their Correction with GABA Derivative
- Authors: Ordyan N.E.1, Akulova V.K.2, Mironova V.I.2, Otellin V.A.1
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Affiliations:
- Laboratory of Ontogenesis of the Nervous System
- Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology of the Russian Academy of Sciences
- Issue: Vol 164, No 2 (2017)
- Pages: 118-122
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239412
- DOI: https://doi.org/10.1007/s10517-017-3938-0
- ID: 239412
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Abstract
We studied the effects of acute normobaric hypoxia on postnatal day 2 (model of preterm pregnancy) on reflex activity and behavior of juvenile male Wistar rats and the possibility of correction of behavioral deficit by administration of GABA derivative Salifen after hypoxia. It is shown, that perinatal hypoxia impaired righting reflex and forelimb grip strength and increased motor activity in juvenile male rats. Administration of Salifen for 14 days in a dose of 15 mg/kg improved reflex activity and behavior of rats, which indicates the prospect of further study of the therapeutic efficacy of this drug on models of neonatal encephalopathy.
About the authors
N. E. Ordyan
Laboratory of Ontogenesis of the Nervous System
Author for correspondence.
Email: neo@infran.ru
Russian Federation, St. Petersburg
V. K. Akulova
Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology of the Russian Academy of Sciences
Email: neo@infran.ru
Russian Federation, St. Petersburg
V. I. Mironova
Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology of the Russian Academy of Sciences
Email: neo@infran.ru
Russian Federation, St. Petersburg
V. A. Otellin
Laboratory of Ontogenesis of the Nervous System
Email: neo@infran.ru
Russian Federation, St. Petersburg
