Email this article Study of the Association of Polymorphisms of p53 and p21 with the Risk of Development of Stomach Cancer
- Authors: Dmitrieva A.I.1,2, Serebryakova V.A.1,2, Rakitin S.S.1, Kudyakov L.A.2, Novitskii V.V.1,3, Yankovich K.I.1,2, Sevostyanova N.V.1,3
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Affiliations:
- Siberian State Medical University, Ministry of Health of the Russian Federation
- Tomsk Regional Oncology Center
- National Research Tomsk State University
- Issue: Vol 164, No 1 (2017)
- Pages: 95-98
- Section: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/239390
- DOI: https://doi.org/10.1007/s10517-017-3932-6
- ID: 239390
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Abstract
A real-time PCR with hybridization and fluorescent detection was used to analyze the distribution of p53 G215C, p21A1026G, and G369C gene polymorphisms in patients with stomach cancer and healthy subjects. It was found that allele C, genotypes of CC and GC of G215C p53, and G369C p21 polymorphisms and allele A and AA and GA genotypes of A1026G p21 polymorphism are significantly associated with the risk of stomach cancer development.
About the authors
A. I. Dmitrieva
Siberian State Medical University, Ministry of Health of the Russian Federation; Tomsk Regional Oncology Center
Author for correspondence.
Email: alladmitrieva@mail.ru
Russian Federation, Moscow; Tomsk
V. A. Serebryakova
Siberian State Medical University, Ministry of Health of the Russian Federation; Tomsk Regional Oncology Center
Email: alladmitrieva@mail.ru
Russian Federation, Moscow; Tomsk
S. S. Rakitin
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: alladmitrieva@mail.ru
Russian Federation, Moscow
L. A. Kudyakov
Tomsk Regional Oncology Center
Email: alladmitrieva@mail.ru
Russian Federation, Tomsk
V. V. Novitskii
Siberian State Medical University, Ministry of Health of the Russian Federation; National Research Tomsk State University
Email: alladmitrieva@mail.ru
Russian Federation, Moscow; Tomsk
K. I. Yankovich
Siberian State Medical University, Ministry of Health of the Russian Federation; Tomsk Regional Oncology Center
Email: alladmitrieva@mail.ru
Russian Federation, Moscow; Tomsk
N. V. Sevostyanova
Siberian State Medical University, Ministry of Health of the Russian Federation; National Research Tomsk State University
Email: alladmitrieva@mail.ru
Russian Federation, Moscow; Tomsk
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