Study of the Association of Polymorphisms of p53 and p21 with the Risk of Development of Stomach Cancer
- 作者: Dmitrieva A.1,2, Serebryakova V.1,2, Rakitin S.1, Kudyakov L.2, Novitskii V.1,3, Yankovich K.1,2, Sevostyanova N.1,3
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隶属关系:
- Siberian State Medical University, Ministry of Health of the Russian Federation
- Tomsk Regional Oncology Center
- National Research Tomsk State University
- 期: 卷 164, 编号 1 (2017)
- 页面: 95-98
- 栏目: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/239390
- DOI: https://doi.org/10.1007/s10517-017-3932-6
- ID: 239390
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详细
A real-time PCR with hybridization and fluorescent detection was used to analyze the distribution of p53 G215C, p21A1026G, and G369C gene polymorphisms in patients with stomach cancer and healthy subjects. It was found that allele C, genotypes of CC and GC of G215C p53, and G369C p21 polymorphisms and allele A and AA and GA genotypes of A1026G p21 polymorphism are significantly associated with the risk of stomach cancer development.
作者简介
A. Dmitrieva
Siberian State Medical University, Ministry of Health of the Russian Federation; Tomsk Regional Oncology Center
编辑信件的主要联系方式.
Email: alladmitrieva@mail.ru
俄罗斯联邦, Moscow; Tomsk
V. Serebryakova
Siberian State Medical University, Ministry of Health of the Russian Federation; Tomsk Regional Oncology Center
Email: alladmitrieva@mail.ru
俄罗斯联邦, Moscow; Tomsk
S. Rakitin
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: alladmitrieva@mail.ru
俄罗斯联邦, Moscow
L. Kudyakov
Tomsk Regional Oncology Center
Email: alladmitrieva@mail.ru
俄罗斯联邦, Tomsk
V. Novitskii
Siberian State Medical University, Ministry of Health of the Russian Federation; National Research Tomsk State University
Email: alladmitrieva@mail.ru
俄罗斯联邦, Moscow; Tomsk
K. Yankovich
Siberian State Medical University, Ministry of Health of the Russian Federation; Tomsk Regional Oncology Center
Email: alladmitrieva@mail.ru
俄罗斯联邦, Moscow; Tomsk
N. Sevostyanova
Siberian State Medical University, Ministry of Health of the Russian Federation; National Research Tomsk State University
Email: alladmitrieva@mail.ru
俄罗斯联邦, Moscow; Tomsk