Study of the Association of Polymorphisms of p53 and p21 with the Risk of Development of Stomach Cancer


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A real-time PCR with hybridization and fluorescent detection was used to analyze the distribution of p53 G215C, p21A1026G, and G369C gene polymorphisms in patients with stomach cancer and healthy subjects. It was found that allele C, genotypes of CC and GC of G215C p53, and G369C p21 polymorphisms and allele A and AA and GA genotypes of A1026G p21 polymorphism are significantly associated with the risk of stomach cancer development.

作者简介

A. Dmitrieva

Siberian State Medical University, Ministry of Health of the Russian Federation; Tomsk Regional Oncology Center

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Email: alladmitrieva@mail.ru
俄罗斯联邦, Moscow; Tomsk

V. Serebryakova

Siberian State Medical University, Ministry of Health of the Russian Federation; Tomsk Regional Oncology Center

Email: alladmitrieva@mail.ru
俄罗斯联邦, Moscow; Tomsk

S. Rakitin

Siberian State Medical University, Ministry of Health of the Russian Federation

Email: alladmitrieva@mail.ru
俄罗斯联邦, Moscow

L. Kudyakov

Tomsk Regional Oncology Center

Email: alladmitrieva@mail.ru
俄罗斯联邦, Tomsk

V. Novitskii

Siberian State Medical University, Ministry of Health of the Russian Federation; National Research Tomsk State University

Email: alladmitrieva@mail.ru
俄罗斯联邦, Moscow; Tomsk

K. Yankovich

Siberian State Medical University, Ministry of Health of the Russian Federation; Tomsk Regional Oncology Center

Email: alladmitrieva@mail.ru
俄罗斯联邦, Moscow; Tomsk

N. Sevostyanova

Siberian State Medical University, Ministry of Health of the Russian Federation; National Research Tomsk State University

Email: alladmitrieva@mail.ru
俄罗斯联邦, Moscow; Tomsk


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