Email this article Tripeptides Restore the Number of Neuronal Spines under Conditions of In Vitro Modeled Alzheimer’s Disease
- Authors: Kraskovskaya N.A.1, Kukanova E.O.2, Lin’kova N.S.1,2, Popugaeva E.A.1, Khavinson V.K.2,3
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Affiliations:
- Peter the Great Saint Petersburg Polytechnic University
- St. Petersburg Institute of Bioregulation and Gerontology
- I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
- Issue: Vol 163, No 4 (2017)
- Pages: 550-553
- Section: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/239081
- DOI: https://doi.org/10.1007/s10517-017-3847-2
- ID: 239081
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Abstract
In primary culture of mouse hippocampal neurons, peptide EDR (200 ng/ml) under conditions of amyloid synaptotoxicity (a model of Alzheimer’s disease) increased the number of mushroom spines by 71% and returned this parameter to the normal level. Under the same conditions, tripeptide KED (200 ng/ml) increased the number of mushroom spines in hippocampal neurons by 20%. Tripeptide EDR can be recommended for further experimental study as a candidate neuroprotective agent for prevention and treatment of Alzheimer’s disease.
About the authors
N. A. Kraskovskaya
Peter the Great Saint Petersburg Polytechnic University
Email: miayy@yandex.ru
Russian Federation, St. Petersburg
E. O. Kukanova
St. Petersburg Institute of Bioregulation and Gerontology
Email: miayy@yandex.ru
Russian Federation, St. Petersburg
N. S. Lin’kova
Peter the Great Saint Petersburg Polytechnic University; St. Petersburg Institute of Bioregulation and Gerontology
Author for correspondence.
Email: miayy@yandex.ru
Russian Federation, St. Petersburg; St. Petersburg
E. A. Popugaeva
Peter the Great Saint Petersburg Polytechnic University
Email: miayy@yandex.ru
Russian Federation, St. Petersburg
V. Kh. Khavinson
St. Petersburg Institute of Bioregulation and Gerontology; I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: miayy@yandex.ru
Russian Federation, St. Petersburg; St. Petersburg
