Enviar artigo por via de e-mail Tripeptides Restore the Number of Neuronal Spines under Conditions of In Vitro Modeled Alzheimer’s Disease
- Autores: Kraskovskaya N.1, Kukanova E.2, Lin’kova N.1,2, Popugaeva E.1, Khavinson V.2,3
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Afiliações:
- Peter the Great Saint Petersburg Polytechnic University
- St. Petersburg Institute of Bioregulation and Gerontology
- I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
- Edição: Volume 163, Nº 4 (2017)
- Páginas: 550-553
- Seção: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/239081
- DOI: https://doi.org/10.1007/s10517-017-3847-2
- ID: 239081
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Resumo
In primary culture of mouse hippocampal neurons, peptide EDR (200 ng/ml) under conditions of amyloid synaptotoxicity (a model of Alzheimer’s disease) increased the number of mushroom spines by 71% and returned this parameter to the normal level. Under the same conditions, tripeptide KED (200 ng/ml) increased the number of mushroom spines in hippocampal neurons by 20%. Tripeptide EDR can be recommended for further experimental study as a candidate neuroprotective agent for prevention and treatment of Alzheimer’s disease.
Sobre autores
N. Kraskovskaya
Peter the Great Saint Petersburg Polytechnic University
Email: miayy@yandex.ru
Rússia, St. Petersburg
E. Kukanova
St. Petersburg Institute of Bioregulation and Gerontology
Email: miayy@yandex.ru
Rússia, St. Petersburg
N. Lin’kova
Peter the Great Saint Petersburg Polytechnic University; St. Petersburg Institute of Bioregulation and Gerontology
Autor responsável pela correspondência
Email: miayy@yandex.ru
Rússia, St. Petersburg; St. Petersburg
E. Popugaeva
Peter the Great Saint Petersburg Polytechnic University
Email: miayy@yandex.ru
Rússia, St. Petersburg
V. Khavinson
St. Petersburg Institute of Bioregulation and Gerontology; I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: miayy@yandex.ru
Rússia, St. Petersburg; St. Petersburg
