Nephroprotective Effect of EDL Peptide at Acute Injury of Kidneys of Different Genesis

I. I. Zamorskii; T. S. Shchudrova; N. S. Lin’kova; T. E. Nichik; V. Kh. Khavinson

doi:10.1007/s10517-017-3811-1

Nephroprotective Effect of EDL Peptide at Acute Injury of Kidneys of Different Genesis

Authors: Zamorskii I.I.¹, Shchudrova T.S.¹, Lin’kova N.S.²^,3, Nichik T.E.², Khavinson V.K.²^,4
Affiliations:
1. Bukovinian State Medical University
2. St. Petersburg Institute of Bioregulation and Gerontology
3. Peter the Great St. Petersburg Polytechnic University
4. I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Issue: Vol 163, No 3 (2017)
Pages: 389-393
Section: Biogerontology
URL: https://journals.rcsi.science/0007-4888/article/view/238930
DOI: https://doi.org/10.1007/s10517-017-3811-1
ID: 238930

Cite item

Full Text

Open Access
Restricted Access

Access granted
Restricted Access

Subscription Access

Abstract
About the authors
References
Statistics

Abstract

EDL peptide produced a nephroprotective effect on experimental models gentamycin-induced nephropathy and ischemia/reperfusion kidney injury in rats. The nephroprotective effect of EDL peptide manifested in prevention of oliguria and retention azotemia, a decrease in proteinuria and sodium excretion, prevention of critical decrease in activities of antioxidant enzymes, suppression of LPO, and normalization of energy supply to kidneys cells. Our findings confirm the prospects of further studies of the nephroprotective properties of peptide EDL in various pathologies of the kidneys.

Username
Password
Remember me

Forgot password?	Register

Username
Password
Remember me

Forgot password?	Register

Nephroprotective Effect of EDL Peptide at Acute Injury of Kidneys of Different Genesis

Full Text

Abstract

About the authors

I. I. Zamorskii

T. S. Shchudrova

N. S. Lin’kova

T. E. Nichik

V. Kh. Khavinson

This website uses cookies