Combinatorial Screening of Peptides, Specific Ligands of Death Receptor DR5
- Authors: Ukrainskaya V.M.1, Stepanov A.V.1, Belogurov A.A.1, Gabibov A.G.1
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Affiliations:
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Issue: Vol 163, No 3 (2017)
- Pages: 381-384
- Section: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/238923
- DOI: https://doi.org/10.1007/s10517-017-3809-8
- ID: 238923
Cite item
Abstract
Death receptors, in particular DR5, are highly attractive targets of antitumor therapy. The major limitation to application of natural death receptor ligands (TRAIL) is their non-specific cytotoxicity against normal cells. Since TRAIL can also bind decoy receptors (DcR) and prevent induction of apoptosis, the search for new DR-specific ligands is a topical issue. In the present study, we used combinatorial phage display peptide libraries to select a panel of DR5-binding amino acid sequences. A comparative analysis of the selected peptides enabled identification of the consensus sequence responsible for binding to DR5. Integration of this motif into polypeptide cytotoxic agents may provide targeted elimination of malignantly transformed cells.
About the authors
V. M. Ukrainskaya
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: gabibov@mx.ibch.ru
Russian Federation, Moscow
A. V. Stepanov
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: gabibov@mx.ibch.ru
Russian Federation, Moscow
A. A. Belogurov
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: gabibov@mx.ibch.ru
Russian Federation, Moscow
A. G. Gabibov
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: gabibov@mx.ibch.ru
Russian Federation, Moscow
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