Email this article Cysteine-Containing Peptides Stimulate Monocyte Migration through NADPH-Oxidase Activation
- Authors: Krasnikova T.L.1, Arefieva T.I.1, Pylaeva E.A.1, Sidorova M.V.1
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Affiliations:
- Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
- Issue: Vol 163, No 2 (2017)
- Pages: 203-205
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238752
- DOI: https://doi.org/10.1007/s10517-017-3766-2
- ID: 238752
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Abstract
We analyzed migration of monocytes under the effect of apocinin (NADPH inhibitor) and PD98059 (blocker of extracellular MEK/ERK kinase involved in Nox4 oxidase-mediated migration of monocytes). Migration of monocytes stimulated by cysteine-containing peptides (fragments of chemokines with free thiol group MCP-1 and fractalkine) was completely inhibited by apocinin and MEK/ERK blocker. It is assumed that the stimulating effect of cysteine-containing peptides on monocyte migration is mediated by the NADPH-oxidase system, in particular, Nox4.
About the authors
T. L. Krasnikova
Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
Author for correspondence.
Email: tlkrasnikova@gmail.com
Russian Federation, Moscow
T. I. Arefieva
Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
Email: tlkrasnikova@gmail.com
Russian Federation, Moscow
E. A. Pylaeva
Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
Email: tlkrasnikova@gmail.com
Russian Federation, Moscow
M. V. Sidorova
Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
Email: tlkrasnikova@gmail.com
Russian Federation, Moscow
