Enviar artigo por via de e-mail Cysteine-Containing Peptides Stimulate Monocyte Migration through NADPH-Oxidase Activation
- Autores: Krasnikova T.1, Arefieva T.1, Pylaeva E.1, Sidorova M.1
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Afiliações:
- Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
- Edição: Volume 163, Nº 2 (2017)
- Páginas: 203-205
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238752
- DOI: https://doi.org/10.1007/s10517-017-3766-2
- ID: 238752
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Resumo
We analyzed migration of monocytes under the effect of apocinin (NADPH inhibitor) and PD98059 (blocker of extracellular MEK/ERK kinase involved in Nox4 oxidase-mediated migration of monocytes). Migration of monocytes stimulated by cysteine-containing peptides (fragments of chemokines with free thiol group MCP-1 and fractalkine) was completely inhibited by apocinin and MEK/ERK blocker. It is assumed that the stimulating effect of cysteine-containing peptides on monocyte migration is mediated by the NADPH-oxidase system, in particular, Nox4.
Sobre autores
T. Krasnikova
Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: tlkrasnikova@gmail.com
Rússia, Moscow
T. Arefieva
Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
Email: tlkrasnikova@gmail.com
Rússia, Moscow
E. Pylaeva
Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
Email: tlkrasnikova@gmail.com
Rússia, Moscow
M. Sidorova
Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
Email: tlkrasnikova@gmail.com
Rússia, Moscow
