Email this article Antithrombin Activity of Erythrocyte Microvesicles
- Authors: Levin G.Y.1, Sukhareva E.G.1
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Affiliations:
- Department of Gravitational Surgery and Hemodialysis, Volga Federal Medical Research Center, Ministry of Health of the Russian Federation
- Issue: Vol 162, No 6 (2017)
- Pages: 718-721
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238498
- DOI: https://doi.org/10.1007/s10517-017-3696-z
- ID: 238498
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Abstract
Coagulation and optical (based on chromogenic substrate) methods were employed to examine antithrombin activity of erythrocytes and erythrocyte-derived microvesicles isolated days 7, 14, 21, and 28 on erythrocyte storage. The erythrocyte-derived microvesicles decelerated fibrin clot formation from fibrinogen in the presence of exogenous thrombin both with and without heparin. Microvesicles reduced optical density of chromogenic substrate. These data suggest that erythrocyte-derived microvesicles display a prominent antithrombin activity, which significantly increases during erythrocyte storage.
About the authors
G. Ya. Levin
Department of Gravitational Surgery and Hemodialysis, Volga Federal Medical Research Center, Ministry of Health of the Russian Federation
Author for correspondence.
Email: levin@unn.ac.ru
Russian Federation, Nizhny Novgorod
E. G. Sukhareva
Department of Gravitational Surgery and Hemodialysis, Volga Federal Medical Research Center, Ministry of Health of the Russian Federation
Email: levin@unn.ac.ru
Russian Federation, Nizhny Novgorod
