Antithrombin Activity of Erythrocyte Microvesicles
- 作者: Levin G.1, Sukhareva E.1
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隶属关系:
- Department of Gravitational Surgery and Hemodialysis, Volga Federal Medical Research Center, Ministry of Health of the Russian Federation
- 期: 卷 162, 编号 6 (2017)
- 页面: 718-721
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238498
- DOI: https://doi.org/10.1007/s10517-017-3696-z
- ID: 238498
如何引用文章
详细
Coagulation and optical (based on chromogenic substrate) methods were employed to examine antithrombin activity of erythrocytes and erythrocyte-derived microvesicles isolated days 7, 14, 21, and 28 on erythrocyte storage. The erythrocyte-derived microvesicles decelerated fibrin clot formation from fibrinogen in the presence of exogenous thrombin both with and without heparin. Microvesicles reduced optical density of chromogenic substrate. These data suggest that erythrocyte-derived microvesicles display a prominent antithrombin activity, which significantly increases during erythrocyte storage.
作者简介
G. Levin
Department of Gravitational Surgery and Hemodialysis, Volga Federal Medical Research Center, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: levin@unn.ac.ru
俄罗斯联邦, Nizhny Novgorod
E. Sukhareva
Department of Gravitational Surgery and Hemodialysis, Volga Federal Medical Research Center, Ministry of Health of the Russian Federation
Email: levin@unn.ac.ru
俄罗斯联邦, Nizhny Novgorod
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