Email this article Expression of Surface Molecules in Human Mesenchymal Stromal Cells Co-Cultured with Nucleated Umbilical Cord Blood Cells
- Authors: Romanov Y.A.1,2, Balashova E.E.2, Volgina N.E.3, Kabaeva N.V.1, Dugina T.N.2, Sukhikh G.T.3
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Affiliations:
- Russian Cardiology Research-and-Production Complex, Ministry of Health of the Russian Federation
- CryoCenter Cord Blood Bank
- V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- Issue: Vol 162, No 4 (2017)
- Pages: 578-582
- Section: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/238387
- DOI: https://doi.org/10.1007/s10517-017-3662-9
- ID: 238387
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Abstract
We studied the expression of different classes of surface molecules (CD13, CD29, CD40, CD44, CD54, CD71, CD73, CD80, CD86, CD90, CD105, CD106, CD146, HLA-I, and HLA-DR) in mesenchymal stromal cells from human umbilical cord and bone marrow during co-culturing with nucleated umbilical cord blood cells. Expression of the majority of surface markers in both types of mesenchymal stromal cells was stable and did not depend on the presence of the blood cells. Significant differences were found only for cell adhesion molecules CD54 (ICAM-1) and CD106 (VCAM-1) responsible for direct cell—cell contacts with leukocytes and only for bone marrow derived cells.
About the authors
Yu. A. Romanov
Russian Cardiology Research-and-Production Complex, Ministry of Health of the Russian Federation; CryoCenter Cord Blood Bank
Author for correspondence.
Email: romanov@cardio.ru
Russian Federation, Moscow; Moscow
E. E. Balashova
CryoCenter Cord Blood Bank
Email: romanov@cardio.ru
Russian Federation, Moscow
N. E. Volgina
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: romanov@cardio.ru
Russian Federation, Moscow
N. V. Kabaeva
Russian Cardiology Research-and-Production Complex, Ministry of Health of the Russian Federation
Email: romanov@cardio.ru
Russian Federation, Moscow
T. N. Dugina
CryoCenter Cord Blood Bank
Email: romanov@cardio.ru
Russian Federation, Moscow
G. T. Sukhikh
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: romanov@cardio.ru
Russian Federation, Moscow
