Email this article Dependence between LD50 for Rodents and LC50 for Adult Fish and Fish Embryos
- Authors: Zolotarev K.V.1, Belyaeva N.F.1, Mikhailov A.N.1, Mikhailova M.V.1
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Affiliations:
- V. N. Orekhovich Research Institute of Biomedical Chemistry
- Issue: Vol 162, No 4 (2017)
- Pages: 445-450
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238288
- DOI: https://doi.org/10.1007/s10517-017-3636-y
- ID: 238288
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Abstract
We revealed empirical dependences between common logarithm of a ratio of rat oral LD50 to LCa50 for adult fish and lgP for 50 different chemicals; and common logarithm of a ratio of the oral LD50 in rodents to LCe50 for fish embryos and lgP for 30 different chemicals. The dependences were obtained by constructing a trend line between experimental points and calculation of Pearson’s R correlation coefficient as a measure of regression significance. These dependences can show the influence of substance lipophilicity on its toxicity for aquatic organisms comparing to mammals.
About the authors
K. V. Zolotarev
V. N. Orekhovich Research Institute of Biomedical Chemistry
Author for correspondence.
Email: fireaxe@mail.ru
Russian Federation, Moscow
N. F. Belyaeva
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: fireaxe@mail.ru
Russian Federation, Moscow
A. N. Mikhailov
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: fireaxe@mail.ru
Russian Federation, Moscow
M. V. Mikhailova
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: fireaxe@mail.ru
Russian Federation, Moscow
