Dependence between LD50 for Rodents and LC50 for Adult Fish and Fish Embryos

Аннотация

We revealed empirical dependences between common logarithm of a ratio of rat oral LD₅₀ to LC^a₅₀ for adult fish and lgP for 50 different chemicals; and common logarithm of a ratio of the oral LD₅₀ in rodents to LC^e₅₀ for fish embryos and lgP for 30 different chemicals. The dependences were obtained by constructing a trend line between experimental points and calculation of Pearson’s R correlation coefficient as a measure of regression significance. These dependences can show the influence of substance lipophilicity on its toxicity for aquatic organisms comparing to mammals.